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个人简介 Personal Profile 张金兰 博士，研究员，博士研究生导师，北京协和医学院药物分析学系副系主任。1992年至今一致从事药物分析和药物代谢的研究工作，1995年以来作为课题负责人承担和完成了15余项国家和省部级研究课题，2009年度入选教育部新世纪优秀人才计划。联系方式：Email：zhjl@imm.ac.cn社会兼职《药学学报》编委，《中国药学》（英文版）编委，《药物分析杂志》编委，《质谱学报》编委，Journal of Separation Science编委,Frontiers in Molecular Biosciences, Review Editor中国质谱学会常务理事，全国生物计量技术委员会委员，中国分析测试协会青年学术委员会顾问，中国药学会医药生物分析专业委员会副主任委员，中国医药生物技术协会药物分析技术分会常务委员，中国实验室合格评定委员会（CNAS）实验室认可评审员，国际反兴奋剂组织（WADA）实验室认可评审员。学习经历1992年7月毕业于北京医科大学（现北京大学医学部），获理学学士学位；1995年7月毕业于中国协和医科大学（现北京协和医学院），获理学硕士学位；2002年7月毕业于中国协和医科大学（现北京协和医学院），获药物分析学博士学位。工作简历1999年9月至2002年7月在中国医学科学院药物研究所分析室工作，任助研和副研究员。2002年8月至2004年5月：在北京大学医学部药学院进行博士后研究工作。2004年6月作为分析学科引进人才在中国医学科学院药物研究所药物分析研究室工作，任副研究员和研究员。主要研究方向1. 药物分析新技术与方法研究；2. 中草药有效成分分析和代谢研究；3. 代谢组学/脂质组学分析新技术研究和应用；4. 新药质量标准和代谢研究。近年来发表代表性文章已发表SCI论文60余篇，近期发表代表性文章如下：1.  Menglin Li#, Hao Zheng, Miao Lin, Wenwen Zhu, Jinlan Zhang*. Characterization of the protein and peptide of excipient zein by the multienzyme digestion coupled with nano-LC-MS/MS. Food Chemistry, 2020, 321: 126712.2.  Wenwen Zhu#, Menglin Li#, Jinlan Zhang*. Integrating Intact Mass Analysis and Middle-Down Mass Spectrometry Approaches to Effectively Characterize Trastuzumab and Adalimumab Structural Heterogeneity. Journal of Proteome Research, 2020. doi=10.1021/acs.jproteome.0c00373. 3. Zhe Wang#, Fan Zhang#, Wei Liu, Ning Sheng, Hua Sun*, Jinlan Zhang*. Impaired tricarboxylic acid cycle flux and mitochondrial aerobic respiration during isoproterenol induced myocardial ischemia is rescued by bilobalide[J]. Journal of Pharmaceutical Analysis, 2020. doi.org/10.1016/j.jpha.2020.08.008. 4. Ning Sheng#, Hao Zheng#, Min Li, Menglin Li, Zhe Wang, Ying Peng, Haibo Yu*, Jinlan Zhang*. 4,5 caffeoylquinic acid and scutellarin, identified by integrated metabolomics and proteomics approach as the active ingredients of Dengzhan Shengmai, act against chronic cerebral hypoperfusion by regulating glutamatergic and GABAergic synapses. Pharmacological Research, 2020, 152C, 104636.5. Miao Lin , Xiong Chen , Zhe Wang , Dongmei Wang **, Jin-Lan Zhang *，Global profiling and identification of bile acids by multi-dimensional data mining to reveal a way of eliminating abnormal bile acids，Analytica Chimica Acta，10.1016/j.aca.2020.07.067.6. Miao Lin , Zhe Wang , Dongmei Wang, Xiong Chen, Jin-Lan Zhang，A mathematical model-assisted UHPLC-MS/MS method for global profiling and quantification of cholesteryl esters in hyperlipidemic golden hamster，Analytical chemistry, 2019, 91，4504–45127. Hu T, Jia ZX, Zhang JL., Strategy for Comprehensive Profiling and Identification of Acidic Glycosphingolipids Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry, Analytical chemistry, 2017, 89, 7808−78168. Sheng N., Zheng H., Xiao Y., Wang Z., Li ML, zhang JL., Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Chromatography A, 2017，1517，97-107.9. Menglin Li, Ting Hu, Cai Tie, Liang Qu, Hao Zheng, Jinlan Zhang，Quantitative Proteomics and Targeted Fatty Acids Analysis Reveal the Damage of Triptolide in Liver and Kidney. Proteomics, 2017, DOI: 10.1002/pmic.20170000110. Tie C, Hu T, Jia ZX, Zhang JL. Derivatization Strategy for the Comprehensive Characterization of Endogenous Fatty Aldehydes Using HPLC-Multiple Reaction Monitoring. Analytical chemistry, 2016, 88,7762-7768. 11. Hu T, Tie C, Wang Z, Zhang JL. Highly Sensitive and Specific Derivatization Strategy to Profile and Quantitate Eicosanoids by UPLC-MS/MS. Analytica Chimica Acta, 2017,950,108-118. 12. Caihong Wang, Caisheng Wu, Lin Zhang, Jinlan Zhang*. Ultraperformance liquid chromatography-tandem mass spectrometry method for profiling ketolic and phenolic sex steroids using an automated injection program combined with diverter valve switch and step analysis. Analytical chemistry, 2016, 88, 7878-7884. 13. Tie, C.*, Hu, T, Jia, Z. X., Zhang, J. L.** , Automatic Identification Approach for High-Performance Liquid Chromatography-Multiple Reaction Monitoring Fatty Acid Global Profiling. Analytical chemistry , 2015, 87, 8181-8185.