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个人简介 Personal Profile 齐云，男，1964年出生，博士生导师，研究员。1999年从成都中医药大学博士毕业后进入中国中医科学院中西医结合专业博士后流动站，参加国家九五攀登计划预选项目“中药现代化关键问题的基础研究—桂枝汤双向调节作用物质基础和机理研究”。该课题于2007年获中国中西医结合学会科学技术一等奖。2001年出站进入中国医学科学院药用植物研究所，2003年晋升为研究员后已主持或作为主研参与国家及部省级课题20余项，其中主持8项。2010年“濒危药材肉苁蓉种植资源评价、保护和利用”获宁夏回族自治区科学技术进步二等奖；2013年“中药中真菌及真菌毒素污染分析及应用研究”获北京市科学进步三等奖；2015年“符合中药特点的增溶性药用辅料的筛选与评价”获中华中医药学会科学技术二等奖。迄今在国内外以第一作者或通讯作者发表学术论文近100余篇，参编著作9部。现为国家食品药品监督管理局新药评审委员、国家科学技术奖评审专家、中国药理学会中药药理专业委员会委员、《中国药理学通报》、《中国实验方剂学杂志》、《中药药理与临床》等杂志编委。近5年(2018-2023年)以通讯作者(指导研究生)所发表的论文如下：1.  Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Productionby Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes. Int J Mol Sci. 2023, 24(1): 320.2.  Bupleurum chinense exerts a mild antipyretic effect on LPS-induced pyrexia ratsinvolving inhibition of peripheral TNF-α production. J Ethnopharmacol.2023, 310:1163753. Edible O. fragrans flower ameliorates LPS-induced inflammatory responsesthrough suppressing NF-κB and AP-1 pathways. J Funct Foods.2023, 104:1055054. Comparing the effects of three decoctions forcoronavirus disease 2019 on severe acute respiratory syndrome coronavirus2-related toll-like receptors-mediated inflammations. J Tradit Chin Med.2023; 43(1):51-59.5.  Resibufogenin, one of bufadienolides in toad venom,suppresses LPS-induced inflammation via inhibiting NF-κB and AP-1 pathways. Int Immunopharmacol. 2022;113(Pt A):109312.6.  Oral administration of Forsythiasides-rich extractfrom Forsythiae fructus decreases the IgE production through suppressing Th2response in shrimp protein-sensitized BALB/c mice. Phytomedicine Plus.2022, 2(4): 100358.7.  A comparative study of spike protein of SARS-CoV-2and its variant Omicron (B.1.1.529) on some immune characteristics. Sci Rep. 2022, 12:17058.8.  Anti-oxidative and anti-inflammatory activities ofthe ethanol extract of edible flower from Chimonanthus praecox. FrontPharmacol. 2022, 13:1004520.9.  MAPKs/AP-1, not NF-κB, is responsible for MCP-1 production inTNF-α-activated adipocytes. Adipocyte. 2022,11(1):477-486.10.  Aloe-emodin,a naturally occurring anthraquinone, is ahighly potent mast cell stabilizer through activating mitochondrial calciumuniporter. Biochem Pharmacol. 2021, 186:114476.11. Forsythiasides-rich extract from Forsythiae Fructusinhibits mast cell degranulation by enhancing mitochondrial Ca2+ uptake.Front Pharmacol. 2021, 12:696729.12.  Sophoraflavanone M, aprenylated flavonoid from Sophora flavescens Ait., suppresses pro-inflammatorymediators through both NF-κB and JNK/AP-1 signaling pathways in LPS-primedmacrophages. Eur J Pharmacol. 2021, 907:174246.13.  肥大细胞在脂肪组织中的生理与病理作用. 中国病理生理杂志. 2021, 37(1): 151-158.14.  代谢性炎症在代谢综合征中的作用. 生命科学. 2021, 33(1): 15-25.15.  Amlexanox exerts anti-inflammatoryactions by targeting phosphodiesterase 4B in lipopolysaccharide-activatedmacrophages. BBA-Molecular Cell Research. 2020, 1867:118766.16.  Isodeoxyelephantopin,asesquiterpene lactone from Elephantopus scaber Linn., inhibits pro-inflammatorymediators’ production through both NF-κB and AP-1 pathways in LPS-activatedmacrophages. Int Immunopharmal. 2020, 84:106528.17.  Lucyoside B,a triterpenoidsaponin from Luffa cylindrica, inhibits the production of inflammatory mediatorsvia both nuclear factor-κB and activator protein-1 pathways in activatedmacrophages. J Funct Foods. 2020, 69:103941.18.  Qing-Kai-Ling injectioninduces immediate hypersensitivity reaction via the activation of anaphylatoxinC3. Front Pharmacol. 2020, 10:1524.19.  Ethanol extract of Elephantopusscaber Linn.Attenuates inflammatory response via the inhibition of NF-κBsignaling by dampening p65-DNA binding activity in lipopolysaccharide-activatedmacrophages. J Ethnopharmacol. 2020, 25;250:112499.20.  Penicillin causes non-allergicanaphylaxis by activating the contact system. Sci Rep. 2020, 10(1):14160.21.  肥大细胞在肠易激综合症中的作用研究进展. 中国药理学通报. 2020, 36(2): 149-153.22.  Canscora lucidissima, a Chinesefolk medicine, exerts anti-inflammatory activities by inhibiting thephosphorylation of ERK1/2 in LPS-activated macrophages. BMC ComplementAltern Med. 2019, 19(1):371.23.  经皮致敏小鼠肠道过敏模型的建立与评价. 中国实验动物学报. 2019, 27(5):619-625.24.  Shuang-Huang-Lian AttenuatesAirway Hyperresponsiveness and Inflammation in a Shrimp Protein-Induced MurineAsthma Model. Evid Based Complement Alternat Med. 2019: 4827342. 25.  双黄连注射液对I型超敏反应性炎症的抑制作用. 中国药理学与毒理学杂志. 2018, 32(8): 627-633.26.  注射用灯盏花素对脂多糖致巨噬细胞炎症损伤的抑制作用. 中国药理学与毒理学杂志. 2018, 32(10): 783-789.27.  Shuang-Huang-Lian injectioninduces an immediate hypersensitivity reaction via C5a but not IgE. Sci Rep.2018, 8(1):3572.28.  Shuang-Huang-Lian preventsbasophilic granulocyte activation to suppress Th2 immunity. BMC ComplementAltern Med. 2018,18(1):2.29.  Dietary flavone tectochrysinexerts anti-inflammatory action by directly inhibiting MEK1/2 inLPS-primed macrophages. Mol Nutr Food Res. 2018, 62(2):1700288.30.  Obacunone causes sustainedexpression of MKP-1 thus inactivating p38 MAPK to suppress pro-inflammatorymediators throughintracellular MIF. J Cell Biochem. 2018, 119(1):837-849.