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个人简介 徐沈远，男，汉族，1991年出生，浙江仙居人。毕业于迈阿密大学(俄亥俄州)化学与生物化学学院，博士(后)，近年在“PNAS”，"PLoS Pathogens"，“Biotechnology and Bioengineering”等期刊杂志发表论文二十余篇。目前主持国家青年基金1项，国家重点研发计划子课题1项，参加国家自然科学基金面上项目2项。主要从事生物催化，酶的结构和功能，晶体学，核磁共振波谱学等方向的研究工作。 教学与课程 本科生：酶工程（浙江省一流课程）研究生：酶学与酶工程                生物仪器分析 育人成果 科研项目 1. 国家重点研发计划项目，新型化学-酶偶联催化技术创建与应用(2021YFC2102900)。子课题负责人，110万。2. 国家青年基金，C端环区调控醛酮还原酶立体选择性的分子机制解析及催化性能强化。课题负责人，30万元。 科研成果 代表性论文论著2024年：1.Xu, Shen‐Yuan, Rong‐Liang Chu, Hua‐Tao Liu, Chun‐Yue Weng, Ya‐Jun Wang, and Yu‐Guo Zheng. Computer‐directed rational design enhanced the thermostability of carbonyl reductase LsCR for the synthesis of ticagrelor precursor. Biotechnology and Bioengineering (2024).2023年：1.Xu, Shen‐Yuan, Lei Zhou, Ying Xu, Han‐Yue Hong, Chen Dai, Ya‐Jun Wang, and Yu‐Guo Zheng. Recent advances in structure‐based enzyme engineering for functional reconstruction. Biotechnology and Bioengineering 120, no. 12 (2023): 3427-3445.2.Dai, Chen, Hai‐Xing Cao, Jia‐Xin Tian, Yan‐Chi Gao, Hua‐Tao Liu, Shen‐Yuan Xu, Ya‐Jun Wang, and Yu‐Guo Zheng. Structural‐guided design to improve the catalytic performance of aldo‐keto reductase KdAKR. Biotechnology and Bioengineering 120, no. 12 (2023): 3543-3556.3.Zhang, Wen, Shu-Fang Li, Jia-Qi Zhu, Hai-Xing Cao, Hua-Tao Liu, Zi-Qing Shao, Shen-Yuan Xu, Ya-Jun Wang, and Yu-Guo Zheng. Constructing a continuous-flow bioreactor with co-immobilized KmAKR and BmGDH for synthesizing tert-butyl 6-cyano-(3R, 5R)-dihydroxyhexanoate. Biochemical Engineering Journal 197 (2023): 108964.2022年：1.Li, Shu-Fang, Shen-Yuan Xu, Ya-Jun Wang, and Yu-Guo Zheng. Tailoring pullulanase PulAR from Anoxybacillus sp. AR-29 for enhanced catalytic performance by a structure-guided consensus approach. Bioresources and Bioprocessing 9, no. 1 (2022): 25.2.Liu, Hua-Tao, Chun-Yue Weng, Shen-Yuan Xu, Shu-Fang Li, Ya-Jun Wang, and Yu-Guo Zheng. Directed evolution of a carbonyl reductase LsCR for the enantioselective synthesis of (1S)-2-chloro-1-(3, 4-difluorophenyl) ethanol. Bioorganic Chemistry 127 (2022): 105991.3.Qiu, Shuai, Shen-Yuan Xu, Ya-Jun Wang, and Yu-Guo Zheng. Chemoenzymatic catalysis of tert-butyl 6-cyano-(3R, 5R)-dihydroxyhexanoate by aldo-keto reductase coupled with composite Fe3O4 nanozyme scaffold. Chemical Engineering Science 261 (2022): 117935.4.Cheng, Feng, Wei-Bang Xie, Xiao-Fan Gao, Rong-Liang Chu, Shen-Yuan Xu, Ya-Jun Wang, and Yu-Guo Zheng. Development of a new chemo-enzymatic catalytic route for synthesis of (S)− 2-chlorophenylglycine. Journal of Biotechnology 358 (2022): 17-24.2021年：1. Xu, Shenyuan, Kristen Rose McGinnis, Yang Liu, Pengwei Huang, Ming Tan, Michael Robert Stuckert, Riley Erin Burnside et al. "Structural basis of P [II] rotavirus evolution and host ranges under selection of histo-blood group antigens." Proceedings of the National Academy of Sciences 118, no. 36 (2021).2. Standage, Stephen W., Shenyuan Xu, Lauren Brown, Qing Ma, Adeleine Koterba, Patrick Lahni, Prasad Devarajan, and Michael A. Kennedy. NMR-based serum and urine metabolomic profile reveals suppression of mitochondrial pathways in experimental sepsis-associated acute kidney injury. American Journal of Physiology-Renal Physiology 320, no. 5 (2021): F984-F1000.3.Weng, Chun-Yue, Chao-Er Wang, Wei-Bang Xie, Shen-Yuan Xu, Ya-Jun Wang, and Yu-Guo Zheng. Comparative proteome analysis of Actinoplanes utahensis grown on various saccharides based on 2D-DIGE and MALDI-TOF/TOF-MS. Journal of Proteomics 239 (2021): 104193.4.Qiu, Shuai, Shen‐Yuan Xu, Shu‐Fang Li, Kang‐Ming Meng, Feng Cheng, Ya‐Jun Wang, and Yu‐Guo Zheng. Fluorescence‐based screening for engineered aldo‐keto reductase KmAKR with improved catalytic performance and extended substrate scope. Biotechnology Journal 16, no. 9 (2021): 2100130.5.Yi, Yunlei, Shenyuan Xu, Andrey Kovalevsky, Xia Zhang, Dongyang Liu, and Qun Wan. Characterization and structural analysis of a thermophilic GH11 xylanase from compost metatranscriptome. Applied Microbiology and Biotechnology 105 (2021): 7757-7767.6.Li, Shu‐Fang, Jian‐Yong Xie, Shuai Qiu, Shen‐Yuan Xu, Feng Cheng, Ya‐Jun Wang, and Yu‐Guo Zheng. Semirational engineering of an aldo–keto reductase KmAKR for overcoming trade‐offs between catalytic activity and thermostability. Biotechnology and Bioengineering 118, no. 11 (2021): 4441-4452.7.Feng, Jianwei, Shenyuan Xu, Ruirui Feng, Andrey Kovalevsky, Xia Zhang, Dongyang Liu, and Qun Wan. Identification and structural analysis of a thermophilic β-1, 3-glucanase from compost. Bioresources and Bioprocessing 8 (2021): 1-12.2020年：1. Xu, Shenyuan, and Michael A. Kennedy. "Structural dynamics of pentapeptide repeat proteins." Proteins: Structure, Function, and Bioinformatics 88, no. 11 (2020): 1493-1512.2.  Xu, Shenyuan, Luay U. Ahmed, Michael Robert Stuckert, Kristen Rose McGinnis, Yang Liu, Ming Tan, Pengwei Huang et al. "Molecular basis of P [II] major human rotavirus VP8* domain recognition of histo-blood group antigens." PLoS pathogens 16, no. 3 (2020): e1008386.3. Yang, Kundi, Arpad Somogyi, Caitlyn Thomas, Huan Zhang, Zishuo Cheng, Shenyuan Xu, Callie Miller et al. Analysis of barrel-aged Kentucky bourbon whiskey by ultrahigh resolution mass spectrometry. Food Analytical Methods 13 (2020): 2301-2311.2019年：1. Petrova, Irina, Shenyuan Xu, William C. Joesten, Shuisong Ni, and Michael A. Kennedy. Influence of drying method on NMR-based metabolic profiling of human cell lines. Metabolites 9, no. 11 (2019): 256.2017年：1. Xu, Shenyuan, Brian N. Long, Gabriel H. Boris, Anqi Chen, Shuisong Ni, and Michael A. Kennedy. "Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras." Acta Crystallographica Section D: Structural Biology 73, no. 12 (2017): 970-984.2. Liu, Yang, Shenyuan Xu, Andrew L. Woodruff, Ming Xia, Ming Tan, Michael A. Kennedy, and Xi Jiang. "Structural basis of glycan specificity of P [19] VP8*: implications for rotavirus zoonosis and evolution." PLoS pathogens 13, no. 11 (2017): e1006707.3. Xu, Shenyuan, Shuisong Ni, and Michael A. Kennedy. "NMR analysis of amide hydrogen exchange rates in a pentapeptide-repeat protein from A. thaliana." Biophysical journal 112, no. 10 (2017): 2075-2088.