石硕教师主页

个人简介 Personal Profile 石硕，同济大学化学科学与工程学院教授，博士生导师，普通化学教研室主任，普通化学课程负责人（国家级精品课程），毕业于中山大学 （2007年），获化学生物学专业理学博士学位（导师：中国科学院院士，计亮年教授），美国加州理工学院访问学者（2012-2013年，导师：美国国家科学院院士：Professor J. K. Barton）。荣获上海市科技进步奖，上海医学科技奖青年奖，同济大学青年岗位能手，同济大学优秀青年教师，同济大学骨干教师等荣誉。研究兴趣集中于：(1) 药物设计及癌症的多模式治疗(化疗、免疫治疗、基因治疗、光疗等）；(2) 生物传感器构筑及疾病基因诊断；(3) DNA分子器件设计。目前已在Advanced Materials, CoordinationChemistry Reviews, Materials Horizons, Chemical Science, Small, Biosensorsand Bioelectronics, Journal of Controlled Release, ACS Materials Letters, Advanced  Healthcare Materials, ACS Applied Materials & Interfaces, NanoResearch, Acta Biomaterialia, Journal of Nanobiotechnology, MaterialsToday Bio, Chemical Communications, Chemistry. A European. Journal, Cancers,Nanoscale, Advanced Therapeutics, Communications Biology, Inorganic ChemistryFrontiers, Inorganic Chemistry, Journal of Materials Chemistry. B, Journal ofPhysical Chemistry B, Biochemistry, Dalton Trans 等期刊发表SCI收录论文100余篇，h因子31，论文被引用3000余次，多篇研究论文被评为该领域的TOP 10论文，并有多项已授权发明专利。     担任Advanced Materials, Advanced Functional Materials, Chemical Science, Small, Chem. Comm, Chem. Eur. J., Biosensors and Bioelectronics, Journal of Materials Chemistry A/B, Inorganic Chemsitry, Biochemistry, Methods, Dalton Trans, Physical Chemistry Chemical Physics, Analyst, Metallomics, Molecular BioSystems, Biochimie, Journal of Inorganic Biochemistry, European Journal of Medicinal Chemistry, DNA and Cell Biology等50余种期刊审稿专家。     担任 Cancrers, American Journal of Biosensor & Bioelectronics, Journal of Biochemistry and Molecular Biology Research, Telomere and Telomerase 编委（Editorial Board Member). 研究方向Research Directions 化学生物学 2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。 团队展示 课题组主页：https://www.x-mol.com/groups/shishuo 项目情况 (1) 可调控免疫应答的新型奥沙利铂前药分子构建及其增敏铁死亡研究 (国家自然科学基金)(2) 基于DNA构象变化的逻辑门网络化构筑及其分子密码应用 (国家自然科学基金)(3) G-四链体稳定与解旋的分子构筑及肌萎缩侧索硬化症(ALS)的基因疗法初探 (国家自然科学基金)(4) 靶向癌基因启动子区G-四链体的钌配合物的合成及抗肿瘤机制研究(国家自然科学基金)(5) 手性钌铱双核配合物对G-quadruplex和I-motif的选择性识别研究 (国家自然科学基金)(6) 重编程有氧呼吸的新型奥沙利铂前药递送系统的构建及其增敏铜死亡研究 (上海市自然科学基金)(7) 新型药物制剂递释系统的设计及其多通路协同抗肿瘤研究 (同济大学自主原创重点项目)(8) DNA生物传感器的构建与若干疾病的分子诊断研究 (中央高校基本科研业务费)(9) 单双核钌配合物与DNA的键合性质研究 (同济大学优秀青年人才)(10) 小分子药物设计合成及抗肿瘤活性测试研究 (横向项目) 报考意向 招生信息 化学科学与工程学院 硕士研究生 序号 专业 招生人数 年份 1 化学（博士） 1 2023 博士研究生 序号 专业 招生人数 年份 1 化学（博士） 1 2023 报考意向 姓名: 手机号码： 邮箱： 毕业院校： 所学专业： 报考类型： 博士 硕士 个人简历*： 上传附件 支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg 成绩单*： 上传附件 支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg 其他材料： 上传附件 支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg 备注： 提交 科研项目（主持） (1) 可调控免疫应答的新型奥沙利铂前药分子构建及其增敏铁死亡研究 (国家自然科学基金)(2) 基于DNA构象变化的逻辑门网络化构筑及其分子密码应用 (国家自然科学基金)(3) G-四链体稳定与解旋的分子构筑及肌萎缩侧索硬化症(ALS)的基因疗法初探 (国家自然科学基金)(4) 靶向癌基因启动子区G-四链体的钌配合物的合成及抗肿瘤机制研究(国家自然科学基金)(5) 手性钌铱双核配合物对G-quadruplex和I-motif的选择性识别研究 (国家自然科学基金)(6) 重编程有氧呼吸的新型奥沙利铂前药递送系统的构建及其增敏铜死亡研究 (上海市自然科学基金)(7) 新型药物制剂递释系统的设计及其多通路协同抗肿瘤研究 (同济大学自主原创重点项目)(8) DNA生物传感器的构建与若干疾病的分子诊断研究 (中央高校基本科研业务费)(9) 单双核钌配合物与DNA的键合性质研究 (同济大学优秀青年人才)(10) 小分子药物设计合成及抗肿瘤活性测试研究 (横向项目) 研究成果(时间倒序） 70. Chunhui Wang, Xinda Yang, Chunyan Dong, Keke Chai,Juan Ruan and Shuo Shi*, Cu-related agents for cancer therapies,Coordination Chemistry Reviews, 2023, 487, 215156. (IF=24.833)69. Yiming Rao‡, Ting Fan‡, Lulu Zhou, Kang Fang,Yanting Sun, Xiaochun Hu, Anqi Wang, Ruihao Li, Zhounan Zhu, Chunyan Dong*, ShuoShi*, A positive self-sufficient H2O2 and acidityenhancement circulation for boosting chemodynamic-photothermal-starvationsynergistic therapy, Journal of Controlled Release, 2023, 354, 701-712. (IF = 11.467) 68. Mohamed NabeelMattath, Debasis Ghosh, Chunyan Dong, ThimmaiahGovindaraju*, and Shuo Shi*, Mercury mediated DNA-Au/Agnanoclusters ensemble to generate gray code encoder for biocomputing, MaterialsHorizons, 2022, 9, 2109-2114. Outside Front Cover (IF = 15.717)67. Xiaochun Hu†, Ruihao Li†,Wenjing Wu, Kang Fang, Zhounan Zhu, Yixuan Wang, Lulu Zhou, Mengyao, Chen,Chunyan Dong*, and Shuo Shi*, A Fe(III)-porphyrin-oxaliplatin(IV)nanoplatform for enhanced ferroptosis and combined therapy, Journal of Controlled Release, 2022, 348,660–671. (IF = 11.467)  66. Mengyao Chen†, JingxianYang†, Chunyan Dong* and Shuo Shi*, A dual-responsive and ROS-augmentednanoplatform for chemo/photodynamic/chemodynamic combination therapy of triplenegative breast cancer, ACS Appl. Mater. Interfaces 2022, 14, 1, 57–68. (IF=10.383) 65. Mengyao Chen, ChunyanDong* and Shuo Shi*, An overview of recent advancement onmanganese-based nanostructures and their application for ROS-mediated tumortherapy, Acs Materials Letters, 2022, 4, 2415-2433. (IF=11.17)64. Ruihao Li†, Xiaochun Hu†,Fangjian Shang, Wenjing Wu, Haijun Zhang, Yixuan Wang, Jiawei Pan, Shuo Shi* andChunyan Dong*, Treatment of triple negative breast cancer by near infraredlight triggered mild temperature photothermal therapy combined withoxygen-independent cytotoxic free radicals, Acta Biomaterialia, 2022,218–229.  (IF = 10.633)63. Xiaochun Hu†, Hui Li†, Ruihao Li, Sufeng Qiang,Mengyao Chen, Shuo Shi* and Chunyan Dong*, A phase-change mediated intelligentnanoplatform for chemo/photothermal/photodynamic therapy of cancer, AdvancedHealthcare Materials, 2022, 2202245. (IF=11.092)62. Yanting Sun†, KangFang†, Xiaochun Hu, Jingxian Yang, Zhengyang Jiang, Lei Feng, Ruihao Li,Yiming Rao, Shuo Shi* and Chunyan Dong* , NIR-light-controlled G-quadruplexhydrogel for synergistically enhancing photodynamic therapy viasustained delivery of metformin and catalase-like activity in breastcancer, Materials Today Bio, 2022, 16100375. (IF = 10.761) 61. Lei Feng†, Mengyao Chen†,Ruihao Li, Lulu Zhou, Chunhui Wang, Pingting Ye, Xiaochun Hu, Jingxian Yang, YantingSun, Zhounan Zhu, Keke Chai, Kang Fang, Shuo Shi* and Chunyan Dong*, Biodegradableoxygen-producing manganese-chelated metal organic frameworks for tumor-targetedsynergistic chemo/photothermal/ photodynamic therapy, Acta Biomaterialia,2022, 138, 463–477. (IF = 10.633)60. Sufeng Qiang†, Xiaochun Hu†,Ruihao Li, Wenjing Wu, Kang Fang, Hui Li, Yanting Sun, Shujing Liang, WenrongZhao, Mengjie Wang, Yun Lin, Shuo Shi*, and Chunyan Dong*, CuS nanoparticles-loadedand cisplatin prodrug conjugated Fe(III)-MOFs forMRI-guided combination of chemotherapy andNIR-II photothermal, ACS Appl. Mater. Interfaces, 2022, 14,32, 36503–36514. (IF =10.383)59. Pinting Ye, Lei Feng, Shuo Shi*, Chunyan Dong*, Themechanisms of lncRNA-mediated multidrug resistance and the clinical applicationprospects of lncRNAs in breast cancer, Cancers, 2022, 14(9),2101. (IF = 6.575)58. Jie Liu†, Xiaochun Hu†, LeiFeng, Yun Lin, Shujing Liang, Zhounan Zhu, Shuo Shi* and Chunyan Dong*, Carbonicanhydrase IX‑targeted H‑APBC nanosystem combined with phototherapy facilitatesthe efficacy of PI3K/mTOR inhibitor and resists HIF‑1α‑dependent tumor hypoxia adaptation, Journal of Nanobiotechnology, 2022, 20, 187. (IF =9.429)57. Lulu Zhou#, JinjinChen#, Ruihao Li, Lizhen Wei, Haitao Xiong, Chunhui Wang, Keke Chai,Mengyao Chen, Zhounan Zhu, Tianming Yao, Yun Lin, Chunyan Dong* and ShuoShi*, Metal-polyphenol-network coated prussian blue nanoparticles forsynergistic ferropotosis and apoptosis via triggered GPX4 inhibition andconcurrent in situ bleomycin toxification, Small, 2021, 17, 2103919. (IF=15.153)56. Lulu Zhou#, Jinjin Chen#, YunhaoSun, Keke Chai, Zhounan Zhu, Chunhui Wang,  Mengyao Chen, Wenmei Han,Xiaochun Hu, Ruihao Li,  Tianming Yao, Hui Li, Chunyan Dong* andShuo Shi*, A self-amplifiednanocatalytic system for achieving "1+1+1>3" chemodynamic therapyon triple negative breast cancer, Journal of Nanobiotechnology, 2021, 19, 261.55. Mengyao Chen, ChunyanDong* and Shuo Shi*, Nanoparticle-mediated siRNA delivery andmultifunctional modification strategies for effective cancer therapy, AdvancedMaterials Technology, 2021, 202001236. 54. Xiaochun Hu#,Yonglin Lu# , Wenrong Zhao, MenglinSun, Ruihao Li, Lei Feng, Tianming Yao, Chunyan Dong*, ShuoShi*, A PDA-DTC/Cu-MnO2 nanoplatformfor MR imaging and multi-therapy of triple-negative breast cancer, Chem. Comm, 2021, 57, 4158-4161.53. Wenrong Zhao#,Xiaochun Hu#, Wenhui Li, Ruihao Li,Jinjin Chen, Lulu Zhou, Sufeng Qiang, Shuo Shi*, and ChunyanDong*, M2-like TAMs functionreversal contributes to breast cancer eradication by combination dual immunecheckpoint blockade and photothermal Therapy, Small, 2021, 17, 2007051. 52.YantingSun†, Yuling Li†, Shuo Shi*, and Chunyan Dong*, Exploiting a newapproach to destroy the barrier of tumor microenvironment: nano-architecturedelivery systems, Molecules 2021, 26(9), 2703. 51. Jinjin Chen#, Lulu Zhou#,Chunhui Wang, Yunhao Sun, Yonglin Lu, Ruihao Li, Xiaochun Hu, Mengyao Chen, LvChen, Tianming Yao, Shuo Shi,*and Chunyan Dong*, MultifunctionalSN38-conjugated nanosystem for defeating myelosuppression and diarrhea inducedby irinotecan on esophageal cancer, Nanoscale, 2020, 12, 21234-21247.  50. Jouharsha Afthab, Nafeesa Khatoon,Lulu Zhou, Tianming Yao, and Shuo Shi*,Hepatoprotective Angelica sinensis silver nanoformulation against multidrugresistant bacteria and the integration of multicomponent logic gate system,Nanoscale, 2020, 12, 19149–19158. 49. Chunhui Wang, Jingxian Yang,Chunyan Dong* and Shuo Shi*,Glucose oxidase related cancer therapies, Adv. Therap., 2020, 2000110. 48. Xiaochun Hu,#Yonglin Lu,# Lulu Zhou, Lv Chen, Tianming Yao, Liang Shujing, Chunyan Dong,* ShuoShi*, Post syntheses strategy to integrate porphyrinic metal-organicframeworks with CuS NPs for synergistic enhanced phototherapy, J. Mater. Chem.B, 2020, 8, 935-944. 47. Xiaochun Hu, Yonglin Lu,Chunyan Dong, Xuewen Wu, Lulu Zhou, Lv Chen, Tianming Yao*, Shuo Shi*, A Ru(II) polypyridyl alkynecomplex based metal−organic frameworks for combinedphotodynamic/photothermal/chemotherapy, Chem. Eur. J. 2020, 26, 1668 – 1675. 46. Lulu Zhou#, Lv Chen#, Xiaochun Hu, Yonglin Lu, Wenjie Liu, Tianming Yao, ChunyanDong, *and Shuo Shi*, A Cu9S5 nanoparticle-based CpG delivery systemfor synergistic photothermal-, photodynamic- and immunotherapy, Communications Biology, 2020, 3, 343. 45. Ruihao Li#, Yabin Ma#,Xiaochun Hu, Wenjing Wu, Xuewen Wu, Chunyan Dong, Shuo Shi*,Yun Lin*, [Ru(phen)2podppz]2+significantly inhibits glioblastoma growth in vitro and vivo with fewerside-effects compared with cisplatin, Dalton Trans., 2020, 49, 8864 –8871. 44. Jingxian Yang, Chunhui Wang, Shuo Shi*, Chunyan Dong*, Nanotechnologiesfor enhancing cancer immunotherapy, Nano Research, 2020, 13(10): 2595–2616. 43. Wenjie Liu, Xiaochun Hu, LuluZhou, Ying Tu, Shuo Shi*, Tian-Ming Yao*, An orientation-inspiredperspective on molecular inhibitor of tau aggregation by curcumin conjugatedwith Ru(II) complex scaffold, J. Phys. Chem. B,2020, 124, 2343−2353. 42. LvChen#, Lulu Zhou#, Chunhui Wang, Yonglin Lu, Jie Liu,Xiaochun Hu, Tianming Yao, Yun Lin, Shujing Liang, Shuo Shi* and ChunyanDong*, Tumor-targeted drug and CpG delivery systemfor phototherapy and docetaxel-enhanced-immunotherapy with polarization towardM1-type macrophages on triple negative breast cancer, Adv. Mater. 2019,31, 1904997. 41. Xiaochun Hu#,Yonglin Lu#, Xiaoke Shi, Tianming Yao, Chunyan Dong*, Shuo Shi*, Integrating in situformation of nanozymes with mesoporous polydopamine for combined chemo,photothermal and hypoxia-overcoming photodynamic therapy, Chem. Commun., 2019,55, 14785-14788. 40. Xiaochun Hu, Zhenli Xu, Jiwen Hu,Chunyan Dong, Yonglin Lu, Xuewen Wu, Maierhaba Wumaier, Tianming Yao*, ShuoShi*, A redox-activated theranostic nanoplatform: towardglutathione-response imaging guided enhanced photodynamic therapy, Inorg. Chem.Front., 2019, 6, 2865–2872, 39. MaierhabaWumaier, Tian-Ming Yao*, Xiao-Chun Hu, Zhi-An Hu and Shuo Shi*, LuminescentRu(II)-thiols modified silver nanoparticles for lysosome targeted theranostics,Dalton Trans., 2019, 48, 10393–10397. 38. Maierhaba Wumaier, Jing-Jing Shi*,Tian-Ming Yao*, Xiao-Chun Hu, Ru-Ru Gao, Shuo Shi*, G-quadruplex andduplex DNA binding studies of novel ruthenium(II) complexes containingascididemin ligands, Journal of Inorganic Biochemistry, 2019, 196, 110681. 37. Ruimin Zang, XinWang, Yanyan Zhu, Tianming Yao, Shuo Shi*, Label-free molecular probebased on G-quadruplex and strand displacement for sensitive and selectivedetection and naked eye discrimination of Exon 2 Deletion of AIMP2, Chem. Biol.Drug. Des., 2019; 93, 993–998. 36. XiaochunHu, Danjing Yang, Tianming Yao*, Ruru Gao, Maierhaba Wumaier and Shuo Shi*,Multi-factors (Tail/Loop/Link/Ions) regulation for G-quadruplexesenantioselectivity of Δ- and Λ- [Ru(bpy)2(dppz-idzo)]2+,Dalton Trans., 2018, 47, 5422–5430.35. Ao Huang, Luning Zhang, Weiwei Li,Zeyu Ma, Shuo Shi* and Tianming Yao*, Controlled fluorescence quenchingby antibody-conjugated graphene oxide as a mechanism for tau protein sensing,RSOS, 2018, 5, 171808.34. Ru-Ru Gao, Tian-Ming Yao*, Xiao-YanLv, Yan-Yan Zhu, Yi-Wei Zhang and Shuo Shi*, Integration of G-quadruplexand DNA-templated Ag NCs for nonarithmetic information processing, Chemical Science, 2017,8, 4211–4222. 33.Ru-Ru Gao, Shuo Shi*, Yu-Jie Li, Maierhaba Wumaier, Xiao-Chun hu andTian-Ming Yao*, Coordination polymer nanoparticles from nucleotide andlanthanide ions as a versatile platform for color-tunable luminescence andintegrating boolean logic operations, Nanoscale, 2017, 9, 9589–9597.32. Ru-Ru Gao, Shuo Shi*,Ying Zhu, Hai-Liang Huang, and Tian-Ming Yao*, A RET-supported logic gatecombinatorial library to enable modeling and implementation of intelligentlogic functions, Chemical Science, 2016, 7, 1853-1861.31. Juanjuan Li, Xiaochun Hu, Shuo Shi*, Yiwei Zhang and Tianming Yao*, Three label-free thrombinaptasensors based on aptamers and [Ru(bpy)2(o-mopip)]2+,J. Mater. Chem. B, 2016, 4, 1361–1367. 30. Hailiang Huang, ShuoShi*, Xing Gao, Ruru Gao, Ying Zhu, Xuewen Wu, Ruimin Zang, and TianmingYao*, A universal label-free fluorescent aptasensor based on Ru complex andquantum dots for adenosine, dopamine and 17 β-estradiol detection, Biosensors andBioelectronics, 2016, 79, 198–204. 29. Ying Zhu, Xiao-chun Hu, ShuoShi*, Ru-ru Gao, Hai-liang Huang, Yan-yan Zhu, Xiao-yan Lv, Tian-ming Yao*, Ultrasensitive and universal fluorescentaptasensor for the detection of biomolecules (ATP, Adenosine and Thrombin)based on DNA/Ag nanoclusters fluorescence light-up system, Biosensors andBioelectronics, 2016, 79, 205–212.28. XinWang, Lihong Pei, Xiumin Fan, Shuo Shi*, [Ru(L)2(3-tppp)]2+(L=bpy, phen) stabilizes two different forms of the human telomeric G-quadruplexDNA, Inorganic Chemistry Communications, 2016, 72, 7–12. 27. Shuo Shi*, Xing Gao,Hailiang Huang, Juan Zhao, and Tianming Yao, Effect of the ancillary ligands onthe spectral properties and G-quadruplexes DNA binding behaviours: a combinedexperimental and theoretical study, Chem. Eur.J.2015, 21,13390 –13400. 26. Shuo Shi*, Jin-Hong Xu, Xing Gao, Hai-Liang Huang and Tian-MingYao*, Binding behaviours for different types of DNA G-quadruplexes: enantiomersof [Ru(bpy)2(L)]2+ (L= dppz, dppz-idzo), Chem. Eur. J.2015, 21, 11435 – 11445.25. Hailiang Huang, ShuoShi*, Xuyue Zheng, Tianming Yao*, Sensitive detection for coralyne andmercury ions based on homo-A/T DNA by exonuclease signal amplification,Biosensors and Bioelectronics, 2015, 71, 439–444. 24. Xuyue Zheng, Tianming Yao*, Ying Zhu and Shuo Shi*, Cu2+ Modulated silver nanoclusters as anOn-Off-On fluorescence probe for the selective detection of L-histidine,Biosensors and Bioelectronics, 2015,66, 103–108. 23. Xing Gao, Shuo Shi*,Jun-Liang Yao, Juan Zhao and Tian-Ming Yao*, Impacts of terminal modificationof [Ru(phen)2dppz]2+ on the luminescence properties: atheoretical study, Dalton Trans., 2015, 44, 19264–19274. 22. Xiao-Hui Lu, ShuoShi*, Jun-Liang Yao, Xing Gao, Hai-Liang Huang, Tian-Ming Yao*, Twostructurally analogous ruthenium complexes as naked-eye and reversiblemolecular “light switch” for G-quadruplex DNA, Journal of InorganicBiochemistry, 2014, 140, 64-71. 21. Linlin Wang, Tianming Yao*, Shuo Shi*, Yanlin Cao, Wenliang Sun A label-free fluorescent probefor Hg2+ and biothiols based on graphene oxide and Ru-complex,Scientific Reports, 2014, 4, 5320. 20. Yanlin Cao, Shuo Shi*,Linlin Wang, Junliang Yao and Tianming Yao*, Ultrasensitive fluorescencedetection of heparin based on quantum dots and a functional rutheniumpolypyridyl complex, Biosensors and Bioelectronics, 2014, 55, 174-179. 19. Shuo Shi*‡, ShaneGao,‡ Tongcheng Cao, Jie liu, Xing Gao, Jian Hao, Chunyan Lv, Hailiang Huang,Jun Xu*, Tianming Yao*, Targeting human telomeric G-quadruplex DNA andinhibition of telomerase activity with [(dmb)2Ru(obip)Ru(dmb)2]4+,PloS ONE, 2013, 8(12), e84419.18. Shuo Shi*, Xin Wang, Wenliang Sun, Xiangyang Wang, TianmingYao*, Liangnian Ji, Label-free fluorescent DNA biosensors based onmetallointercalators and nanomaterials, Methods, 2013, 64, 305-314.17. Shuo Shi*, Hai-Liang Huang, Xing Gao, Jun-Liang Yao,Chun-YanLv, Juan Zhao, Wen-Liang Sun, Tian-Ming Yao*, Liang-Nian Ji，A comparative study of theinteraction of two structurally analogous ruthenium complexes with humantelomeric G-quadruplex DNA, Journal of Inorganic Biochemistry, 2013,121,19-27.16. Junliang Yao, Xing Gao, Wenliang Sun, Tianming Yao*, Shuo Shi*, and Liangnian Ji, Molecularhairpin: a possible model for inhibition of tau aggregation by tannic acid,Biochemistry 2013, 52, 1893−1902.15. Wenliang Sun, Junliang Yao, Tianming Yao* and Shuo Shi*, Label-free fluorescent DNAsensor for the detection of silver ions based on molecular light switch Rucomplex and unmodified quantum dots, Analyst, 2013,138, 421-424.14. Jun-Liang Yao, Xing Gao, Wenliang Sun, Shuo Shi* and Tian-Ming Yao*, [Ru(bpy)2dppz-idzo]2+:A colorimetric molecular “light switch” and powerful stabilizer forG-quadruplex DNA, Dalton Trans., 2013, 42, 5661–5672.13. Shuo Shi*, Juan Zhao, Xing Gao, Chunyan Lv, LiYang, Jian Hao, Hailiang Huang, Junliang Yao, Wenliang Sun, Tianming Yao*, andLiangnian Ji, Molecular “light switch” for G-quadruplexes DNA: cycling theswitch on and off, Dalton Trans, 2012., 41, 5789–5793. 12. Shuo Shi *, Chunyan Lv, Xing Gao, Juan Zhao,Junliang Yao, Wenliang Sun, Hailing Huang, Tianming Yao*, Liangnian Ji,[Ru(bpy)2(bppp)]2+ binds two different forms of the humantelomeric G-quadruplex structure, Inorganic Chemistry Communications, 2012, 24,212–215.11. Yao Junliang, Gao Xing, Sun Wenliang, Fan Xuezhong, Shi Shuo*, Yao Tianming*, A naked-eyeon–off–on molecular “light switch” based on a reversible “conformationalswitch” of G-quadruplex DNA, Inorg. Chem., 2012,51, 12591-12593.10. Wenliang Sun, Tianming Yao* and Shuo Shi*, A molecular light switch Ru complex and quantum dots forthe label-free, aptamer-based detection of thrombin, Analyst, 2012, 137,1550–1552.9. Dan-Jing Yang, ShuoShi*, Tian-Ming Yao*, Liang-Nian Ji, Cooperative folding of tau peptide bycoordination of group IIB metal cations during heparin-induced aggregation,Biometals, 2012, 25,361–372. 8. Shuo Shi*, Juan Zhao, Xiaoting Geng, Tianming Yao*, HailiangHuang, Tianlin Liu,Lengfeng Zheng, Zonghui Li, DanjingYang, and Liangnian Ji,Molecular “light switch” for G-quadruplexes and i-motif of human telomeric DNA:[Ru(phen)2(dppz)]2+, Dalton Trans, 2010, 39，2490-2493. 7. Shuo Shi *, Xiaoting Geng, Juan. Zhao,Tianming Yao*, Chaoran Wang, DanjingYang, Lengfeng Zheng, Liangnian Ji, Interaction of [Ru(bpy)2(dppz)]2+with human telomeric DNA: preferential binding to G-quadruplexes over i-motif,Biochimie, 2010, 92, 370-377. 6. Shuo Shi*, Tian-ming Yao, Xiao-tingGeng, Ling-feng Jiang, Jie Liu, Qing-yuan Yang, and Liangnian Ji*, Synthesis,characterization and DNA-binding of chiral complexes D- and L- [Ru(bpy)2(pyip)]2+,Chirality, 2009, 21, 276-283. 5. Shuo Shi*, Tian Xie, Tian-Ming Yao*,Chao-Ran Wang, Xiao-Ting Geng, Dan-Jing Yang, Lin-Jie Han, Liang-Nian Ji, Synthesis,characterization, DNA-binding and DNA-photocleavage studies of [Ru(bpy)2(pmip)]2+and [Ru(phen)2(pmip)]2+ (pmip = 2-(2′-pyrimidyl)imidazo[4,5-f][1,10]phenanthroline,Polyhedron, 2009,18, 1355–1361. 4. Shuo Shi, Jie Liu*, Tianming Yao,Xiaoting Geng, Lingfeng Jiang, Qingyuan Yang, Lin Cheng, and Liangnian Ji*,Promoting the formation and stabilization of G-quadruplex by dinuclear RuIIcomplex Ru2(obip)L4, Inorganic Chemistry, 2008, 47 (8),2910-2912. 3. Shuo Shi, Cai-Ping Tan, Jie Liu, and Liang-Nian Ji*, Conformationconversion and stabilization of G-quadruplex by dinuclear RuIIcomplex [(bpy)2Ru(obip)Ru(bpy)2]4+, Journal ofBiomolecular Structure Dynamics, 2007, 24, 706. 2. Shuo Shi, Jie Liu*, Jun Li, Kang-Cheng Zheng, Xiao-Mei Huang,Cai-Ping Tan, Lan-Mei Chen and Liang-Nian Ji*, Synthesis, characterization andDNA-binding of novel chiral complexes D- and L- [Ru(bpy)2L]2+(L= o-mopip and p-mopip), Journal of Inorganic Biochemistry, 100 (2006)385–395. 1. Shuo Shi, Jie Liu*, Jun Li, KangC. Zheng, Cai P. Tan, Lan M. Chen and Liang N. Ji*, Electronic effect ofdifferent positions of the –NO2 group on the DNA-intercalator of chiralcomplexes [Ru(bpy)2L]2+ (L = o-npip, m-npip and p-npip),Dalton Trans., 2005, 2038– 2046. 学生信息 当前位置：教师主页 > 学生信息 入学日期 所学专业 学号 学位 招生信息 当前位置：教师主页 > 招生信息 招生学院 招生专业 研究方向 招生人数 推免人数 考试方式 招生类别 招生年份