袁健教师主页

个人简介 Personal Profile 男，同济大学医学院教授, 同济大学医学院生化与分子生物学系主任，国家杰青及国家优青。袁健教授长期从事DNA损伤修复与肿瘤发生，肿瘤放化疗耐受分子机制研究，原创性阐明多个新的DNA损伤调控因子在肿瘤（卵巢癌、乳腺癌等）发生及放化疗耐药中的关键作用。相关工作发表在Cell， Nature Cell Biology、Molecular Cell，ScienceAdvances，Nature Communications, Genes & Development， EMBO J等杂志。入选教育部新世纪人才计划。担任科技部 973 项目环境应激致血管内皮细胞衰老、损伤及修复的分子机制课题组长。并获得国家自然科学基金重大项目及重大专项等资助。 研究方向Research Directions DNA损伤与肿瘤 2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。 科研项目 1．国家自然科学基金杰出青年项目，DNA损伤应答与肿瘤发生发展2．国家自然科学基金重大项目，真核细胞维持DNA复制叉稳定的机制研究3．国家自然科学基金面上项目，FAK-OTUD4-POLQ信号轴调控微同源介导末端连接修复（MMEJ）及肿瘤耐药的分子机制研究4．国家自然基金委优秀青年项目，DNA损伤与肿瘤发生5．国家自然基金委衰老重大项目培育项目，去泛素化修饰SIRT7调控血管内皮衰老分子机制研究6．国家自然科学基金面上项目，DBC1调节SIRT功能的机制研究及其在肝癌发生的作用7．国家自然科学基金青年项目，G3BP1 在乳腺癌发生中的作用和机制研究8．科技部 973项目，环境应激致血管内皮细胞衰老、损伤及修复的分子机制 9．教育部新世纪人才计划，结肠癌相关分子标记物的功能研究10. 上海市科委浦江人才计划，DBC1与SIRT1协同调控肿瘤发生的分子机制研究 研究成果 1.    HuangJ, Wu C, Kloeber JA, Gao H, Gao M, Zhu Q, Chang Y, Zhao F, Guo G, Luo K, Dai H,Liu S, Huang Q, Kim W, Zhou Q, Zhu S, Wu Z, Tu X, Yin P, Deng M, Wang L,Yuan J*,Lou Z*. SLFN5-mediated chromatin dynamics sculpthigher-order DNA repair topology. Mol Cell. 2023 Feb25:S1097-2765(23)00083-7.2.    ZengX, Zhao F, Cui G, Zhang Y, Deshpande RA, Chen Y, Deng M, Kloeber JA, Shi Y,Zhou Q, Zhang C, Hou J, Kim W, Tu X, Yan Y, Xu Z, Chen L, Gao H, Guo G, Liu J,Zhu Q, Cao Y, Huang J, Wu Z, Zhu S, Yin P, Luo K, Mer G, Paull TT, Yuan J*, Tao K*, Lou Z*. METTL16 antagonizes MRE11-mediatedDNA end resection and confers synthetic lethality to PARP inhibition inpancreatic ductal adenocarcinoma. NatCancer. 2022 Sep;3(9):1088-1104. 3.    ZhaoF, Kim W, Gao H, Liu C, Zhang Y, Chen Y, Deng M, Zhou Q, Huang J, Hu Q, ChenSH, Nowsheen S, Kloeber JA, Qin B, Yin P, Tu X, Guo G, Qin S, Zhang C, Gao M,Luo K, Liu Y, Lou Z*,Yuan J*. ASTE1 promotes shieldin-complex-mediatedDNA repair by attenuating end resection. Nat Cell Biol. 2021 Aug;23(8):894-904. doi: 10.10384.    WuC, Chang Y, Chen J, Su Y, Li L, Chen Y, Li Y, Wu J, Huang J, Zhao F, Wang W,Yin H, Wang S, Jin M, Lou Z, Zhu WG, Luo K, Zhang J*, Yuan J*.USP37 regulates DNA damage responsethrough stabilizing and deubiquitinating BLM. Nucleic Acids Res.2021 Nov 8;49(19):11224-11240. 5.    ZhouQ#, Huang J#, Zhang C#, Zhao F, Kim W, Tu X, Zhang Y, Nowsheen S, Zhu Q, DengM, Chen Y, Qin B, Luo K, Liu B, Lou Z, Mutter RW*, Yuan J*  The bromodomain containing protein BRD-9orchestrates RAD51-RAD54 complex formation and regulates homologousrecombination-mediated repair. Nat Commun. 2020 May26;11(1):2639. 6.    ChenY#, Wu J#, Liang G, Geng G, Zhao F, Yin P, Nowsheen S, Wu C, Li Y, Li L, Kim W,Zhou Q, Huang J, Liu J, Zhang C, Guo G, Deng M, Tu X, Gao X, Liu Z, Chen Y, LouZ, Luo K, Yuan J*. CHK2-FOXK axis promotes transcriptional control ofautophagy programs. Science Advances 2020 Jan 1;6(1):eaax5819.7.    KimW#,Zhao F#,Wu R, Qin S, Nowsheen S, Huang J, Zhou Q, Chen Y, Deng M, Guo G, Luo K, Lou Z*,Yuan J*. ZFP161 regulates replication fork stability and maintenance ofgenomic stability by recruiting the ATR/ATRIP complex. Nat Commun. 2019Nov 22;10(1):5304. doi: 10.1038/s41467-019-13321-z.8.    WuJ#, Chen Y#, Geng G, Li L, Yin P, Nowsheen S, Li Y, Wu C, Liu J, Zhao F,Kim W, Zhou Q, Huang J, Guo G, Zhang C, Tu X, Gao X, Lou Z, Luo K*,Qiao H*, Yuan J*. USP39 regulates DNAdamage response and chemo-radiation resistance by deubiquitinating andstabilizing CHK2.Cancer Letter.2019 May 1;449:114-124.9.    ChenmingWu, Kuntian Luo, Fei Zhao, Ping Yin, Ying Song, Min Deng, Jinzhou Huang, YupingChen, Lei Li, SeungBaek Lee, JungJin Kim, Qin Zhou, Xinyi Tu, Somaira Nowsheen,Qifeng Luo, Xiumei Gao,  Zhenkun Lou*,Zhongmin Liu*, Jian Yuan*.USP20 positively regulates tumorigenesis and chemoresistance through β-cateninstabilization. CellDeath&Differentiation 2018 Nov;25(10):1855-1869. 10.   Li L#, Liu T#, Li Y, Wu C, Luo K, Yin Y, Chen Y, NowsheenS, Wu J, Lou Z*, Yuan J*.The deubiquitinase USP9X promotes tumor cell survival and conferschemoresistance through YAP1 stabilization. Oncogene. 2018 May;37(18):2422-2431.11.   LiY, Luo K, Yin Y, Wu C, Deng M, Li L, Chen Y, Nowsheen S, Lou Z, Yuan J*. USP13 regulates theRAP80-BRCA1 complex dependent DNA damage response. NatCommun. 2017 Jun 1;8: 15752. 12.   LuoK, Li Y, Yin Y, Li L, Wu C, Chen Y, Nowsheen S, Hu Q, Zhang L, Lou Z, Yuan J*.USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKTsignaling. EMBO J 2017 May15; 36 (10):1434-144613.   LiuT#, Yu J#, Deng M, Yin Y, Zhang H, Luo K, Qin B, Li Y, Wu C, Ren T, HanY, Yin P, Kim J, Lee S, Lin J, Zhang L, Zhang J, Nowsheen S, Wang L, Boughey J,Goetz MP, Yuan J*, Lou Z*. CDK46-dependent activation of DUB3 regulatescancer metastasis through SNAIL1. NatCommun 2017 Jan 09; 8:13923 14.   LuoK#, Li L#, Li Y, Wu C, Yin Y, Chen Y, Deng M, Nowsheen S, Yuan J*,Lou Z*. A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51axis in homologous recombination. GenesDev 2016 Dec 01; 30 (23):2581-2595 15.   DengM, Yang X, Qin B, Liu T, Zhang H, Guo W, Lee SB, Kim JJ, Yuan J, Pei H,Wang L, Lou Z. Deubiquitination and Activation of AMPK by USP10. Mol Cell 2016 Feb 18; 61(4):614-2416.   LuoK, Deng M, Li Y, Wu C, Xu Z, Yuan J*, Lou Z*. CDK-mediated RNF4phosphorylation regulates homologous recombination in S-phase. Nucleic Acids Res 2015 Jun 23;43 (11):5465-75 17.   OiN#, Yuan J#, Malakhova M, Luo K, Li Y, Ryu J, Zhang L, Bode AM, Xu Z,Lou Z, Dong Z. Resveratrol induces apoptosis by directly targetingRas-GTPase-activating protein SH3 domain-binding protein 1. Oncogene 2015 May 14; 34 (20):2660-71 18.   LiuT, Lin YH, Leng W, Jung SY, Zhang H, Deng M, Evans D, Li Y, Luo K, Qin B, QinJ, Yuan J*, Lou Z*. A divergent role of the SIRT1-TopBP1 axis inregulating metabolic checkpoint and DNA damage checkpoint. Mol Cell 2014 Dec 4; 56 (5):681-95 19.   YuanJ*, Luo K, DengM, Li Y, Yin P, Gao B, Fang Y, Wu P, Liu T, Lou Z*. HERC2-USP20 axis regulatesDNA damage checkpoint through Claspin. NucleicAcids Res 2014 Dec 01; 42 (21):13110-21 20.   QinB, Gao B, Yu J, Yuan J*, Lou Z*. Ataxia telangiectasia-mutated- andRad3-related protein regulates the DNA damage-induced G2/M checkpoint throughthe Aurora A cofactor Bora protein. JBiol Chem 2013 May 31; 288 (22):16139-44 21.   LuoK, Zhang H, Wang L, Yuan J*, Lou Z*. Sumoylation of MDC1 is importantfor proper DNA damage response. EMBOJ. 2012 Jun 29; 31(13):3008-19. 22.   Yuan J*, Luo K, Liu T, Lou Z*. Regulation of SIRT1 activity by genotoxicstress. Genes Dev. 2012 Apr15; 26 (8):791-6. 23.   Luo K#, Yuan J#, Lou Z. Oligomerization of MDC1 protein isimportant for proper DNA damage response. JBiol Chem. 2011 Aug 12; 286(32):28192-9 24.   Yuan J, Luo K, Zhang L, Cheville JC, Lou Z. USP10 regulates p53localization and stability by deubiquitinating p53. Cell 2010 Feb 05; 140 (3):384-96 25.   Yuan J, Pu M, Zhang Z, Lou Z. Histone H3-K56 acetylation is importantfor genomic stability in mammals. CellCycle 2009 Jun 01; 8 (11):1747-5326.   Yuan J, Minter-Dykhouse K, Lou Z. A c-Myc-SIRT1 feedback loop regulatescell growth and transformation. JCell Biol 2009 Apr 20; 185 (2):203-1127.   Chen X, Gu X, Shan Y, Tang W, Yuan J, Zhong Z, Wang Y,Huang W, Wan B, Yu L. Identification of a novel human lactate dehydrogenasegene LDHAL6A, which activates transcriptional activities of AP1(PMA). Mol Biol Rep 2009 Apr; 36(4):669-7628.   Luo K, Yuan J, Chen J, Lou Z. Topoisomerase IIalphacontrols the decatenation checkpoint. NatCell Biol 2009 Feb; 11 (2):204-10 29.   Guo Z, Yuan J, Tang W, Chen X, Gu X, Luo K, Wang Y, Wan B,Yu L. Cloning and characterization of the human gene RAP2C, a novel member ofRas family, which activates transcriptional activities of SRE. Mol Biol Rep 2007 Sep; 34(3):137-4430.   Tang W, Yuan J, Chen X, Gu X, Luo K, Li J, Wan B, Wang Y,Yu L. Identification of a novel human lysophosphatidic acid acyltransferase,LPAAT-theta, which activates mTOR pathway. JBiochem Mol Biol 2006 Sep 30; 39 (5):626-3531.   Guo Z, Tang W, Yuan J, Chen X, Wan B, Gu X, Luo K, Wang Y,Yu L. BRSK2 is activated by cyclic AMPdependent protein kinase A throughphosphorylation at Thr260. BiochemBiophys Res Commun 2006 Sep 8; 347 (4):867-7132.   Yuan J, Tang W, Luo K, Chen X, Gu X, Wan B, Yu L. Cloning andcharacterization of the human gene DERP6, which activates transcriptionalactivities of p53. Mol Biol Rep2006 Sep; 33 (3):151-833.   Luo K, Li J, Cui Y, Xu M, Yuan J, Tang W, Wan B, Yu L.Identification and characterization of the human SCAN domain zinc-finger geneZNF449. Mol Biol Rep.;33(1)51-7.34.   Luo K, Yuan J, Shan Y, Li J, Xu M, Cui Y, Tang W, Wan B,Zhang N, Wu Y, Yu L. Activation of transcriptional activities of AP1 and SRE bya novel zinc finger protein ZNF445. Gene2006 Feb 15; 367:89-100 35.   Yuan J, Shan Y, Chen X, Tang W, Luo K, Ni J, Wan B, Yu L. Identificationand characterization of RHEBL1, a novel member of Ras family, which activatestranscriptional activities of NF-kappa B.Mol Biol Rep 2005 Dec; 32 (4):205-1436.   Tang W, Yuan J, Chen X, Shan Y, Luo K, Guo Z, Zhang Y, WanB, Yu L. Cloning and characterization of the CDZFP gene which encodes aputative zinc finger protein. DNA Seq2005 Oct; 16 (5):391-637.   Zhang Y, Ni J, Zhou G, Yuan J, Ren W, Shan Y, Tang W, Yu L,Zhao S. Cloning, expression and characterization of the human NOB1 gene. Mol Biol Rep 2005 Sep; 32(3):185-938.   Liu L, Zhang J, Yuan J, Dang Y, Yang C, Chen X, Xu J, Yu L.Characterization of a human regulatory subunit of protein phosphatase 3 gene(PPP3RL) expressed specifically in testis. MolBiol Rep 2005 Mar; 32 (1):41-539.   Liu L, Yang C, Yuan J, Chen X, Xu J, Wei Y, Yang J, Lin G,Yu L. RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3through pseudo-kinase domains. MolCells 2005 Feb 28; 19 (1):39-45 学生信息 当前位置：教师主页 > 学生信息 入学日期 所学专业 学号 学位 招生信息 当前位置：教师主页 > 招生信息 招生学院 招生专业 研究方向 招生人数 推免人数 考试方式 招生类别 招生年份