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个人简介 Personal Profile 教育复旦大学上海医学院 生物化学与分子生物学 博士浙江大学医学院 病理学与病理生理学 硕士温州医学院 临床医学 本科工作 同济大学医学院细胞生物学系；心律失常教育部重点实验室 教授英国剑桥大学干细胞研究所和中科院广州生物医药与健康研究院合作实验室 副教授英国Wellcome Trust 桑格研究所 博士后，专职研究员英国剑桥大学干细胞研究所 博士后英国爱丁堡大学干细胞研究所 博士后复旦大学上海医学院教育部分子医学重点实验室 讲师 研究方向Research Directions 干细胞，体细胞重编程，心脏发育和疾病 2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。 团队展示 在读研究生林哲伊硕博连读研究生华南农业大学  学士郭惠欣博士研究生 山西医科大学联合培养同济大学 硕士同济大学 学士杭成文博士研究生北京大学 硕士扬州大学 学士卢仁宏硕博连读研究生同济大学 学士刘军阳硕博连读研究生烟台大学大学 学士熊惠硕士研究生锦州医科大学 学士张明帅硕士研究生新乡医学院 学士本科实习生王思雨锦州医科大学 项目情况 我们团队的项目主要为：一、多能干细胞状态的转换和体细胞重编程的分子机制1. 聚焦重要的转录因子SALL家族在多能干细胞干性维持、状态转换和三胚层分化过程中的重要作用和分子机制。2. 运用CRISPR/Cas系统筛选与体细胞重编程和多能干细胞分化相关的新基因并研究其机制。二、基于多能干细胞的心脏生物起搏和再生治疗，探究调控心脏发育的分子机制，以阐明心脏疾病的发病机制及新的治疗靶点的研发1. 通过建立高效的心脏起搏细胞分化方法获得功能性的起搏细胞为生物起搏器的研发提供细胞来源。2. 通过诱导多能干细胞分化为心房肌细胞，在体外建立房颤的模型（2D, 3D），探索应用新型纳米材料进行房颤的实验性治疗。3. 研究参与早期心脏发育的重要转录因子的调控机制，通过干细胞来源的心肌细胞建立心脏疾病的体外模型，研发干预的新靶点。 科研项目 国家自然科学基金（面上项目）：Sall1调控多能干细胞naïve和primed状态转化的机制研究 主持国家自然科学基金（基础科学中心项目）：重大心脏病的起源和干预骨干国家自然科学基金（重点项目）：蛋白激酶介导的心肌细胞增殖在心肌损伤修复中的作用及机制研究骨干中国医学科学院：心律的起源与调控创新单元 骨干科技部“一带一路”创新人才交流外国专家项目：纳米生物材料在干细胞治疗心脏疾病中的安全、有效性研究负责人上海市前沿科学研究基地：上海市催化医学前沿科学研究基地 骨干 研究成果 发表论文 1. Le Ni, Bowen Lin, Meiting Shen, Can Li, Lingjie Hu,Fengmei Fu, Lei Chen, JianYang, Dan Shi. PKM2 deficiencyexacerbates gram-negative sepsis-induced cardiomyopathy via disrupting cardiaccalcium homeostasis. Cell Death Discovery, 2022. Dec 23,8(1): 496. Doi: 10.1038/s41420-022-01287-9. 2. Le Ni, Bowen Lin, LingjieHu, Ruoyu Zhang, Fengmei Fu, Meiting Shen, Jian Yang, Dan Shi. Pyruvate kinase M2 protects heart frompressure overload-induced heart failure by phosphorylating RAC1. Journal of the American Heart Association, Co-correspondingauthor, 2022. Jun 7, 11(11):e024854. Doi: 10.1161/JAHA.121.024854 3. Jingjing Liu, Xianting Ke, Luxin Wang, Yangyang Zhang, and Jian Yang. Deficiencyof cold-inducible RNA-binding protein exacerbated monocrotaline-induced pulmonaryartery hypertension through Caveolin1 and CAVIN1. Journal of Cellular andMolecular Medicine, Co-corresponding author, online March 23, 2021.25(10): 4732-4743 Doi: 10.1111/jcmm.16437. 4. Jian Yang,Haifeng Fu, Cheryl Tam and Pentao Liu. Expanded potential: the key to syntheticembryo? Co-corresponding author, Current Opinion in Genetics and Development, 2020, 64: 72-77. 5. NicholasBredenkamp, JianYang, James Clarke, GiulianoGiuseppe Stirparo, Ferdinand von Meyenn, Sabine Dietmann, Duncan Baker,Rosalind Drummond, Yongming Ren, Chuman Wu, Maria Rostovskaya, Sarah Eminli-Meissner,Austin Smith, and Ge Guo. Wnt inhibition facilitates RNA-mediated reprogrammingof human somatic cells to naïve pluripotency. Stem Cell Reports, Co-first author, 2019, 13(6): 1083-1098. 6. Jian Yang, Sandeep S. Rajan,Mathias J Friedrich, Guocheng Lan, Xiangang Zou, Hannes Ponsting, Dimitrios AGaryfallos, Pentao Liu, Allan Bradley, and Emmanouil Metzakopian. Genome-scaleCRISPRa screen identifies novel factors for cellular reprogramming. Stem Cell Reports, Co-first author, 2019, 12(4):754-771.7. Jian Yang, David Ryan, GuochengLan, Xiangang Zou and Pentao Liu. Establishment in vitro of Expanded PotentialStem Cells from mouse preimplantation embryos and embryonic stem cells. Co-corresponding author, Nature Protocols, 2019, 14, 350-378.8. Jian Yang, David J. Ryan, Wei Wang,Jason Cheuk-Ho Tsang, Guocheng Lan, Hideki Masaki, Xuefei Gao, Liliana Antunes,Yong Yu, Zhexin Zhu, Juexuan Wang, Aleksandra A. Kolodziejczyk, Lia S. Campos,Cui Wang, Fengtang Yang, Zhen Zhong, Beiyuan Fu, Melanie Eckersley-Maslin,Michael Woods, Yosuke Tanaka, Xi Chen, Adam C. Wilkinson, James Bussell, JacquiWhite, Ramiro Ramirez-Solis,Wolf Reik, Berthold Göttgens, Sarah A. Teichmann, Patrick P. L. Tam, HiromitsuNakauchi, Xiangang Zou, Liming Lu and Pentao Liu. Establishment of murineexpanded potential stem cells. Nature, Co-first author, 2017, 550, 393-397.DOI: 10. 1038/nature24052 9. Jian Yang, Wei Wang, Jolene Ooi,Lia Campos, Liming Lu and Pentao Liu. Signaling through retinoic acid receptorsis required for reprogramming of both MEFs and EpiSCs to iPSCs. Stem Cells, 2015, 33(5): 1390-1404.10. Jian Yang, Anouk L. van Oosten, Thorold W. Theunissen, Ge Guo, Jose C.R. Silva and Austin Smith Stat3 Activation Is Limiting forReprogramming to Ground State Pluripotency. Cell Stem Cell, 2010, 7(3):319-328. 11. Liudan Jiang, Jiaying Yin,Maoxiang Qian, Shaoqin Rong, Shengqi Zhang, Kejing Chen,Chengchen Zhao, Yuanqing Tan, Jiayin Guo, Hao Chen, Siyun Gao, Tingting Liu, YiLiu, Bin Shen, Jian Yang, Yong Zhang, Fei-Long Meng, Jinchua Hu, Honghui Ma,Yi-Han Chen. UdgX-mediated uracil sequencing at single-nucleotide resolution. J Am Chem Soc, 2022, 143(3): 1323-1331. 12. SiyunGao, Haifeng Sun, Kejing Chen, Xueying Gu, Hongyu Chen, Liudan Jiang, Lei Chen,Shengqi Zhang, Yi Liu, Dan Shi, Dandan Laing, Liang Xu, Jian Yang, Yanjiao Ruan, Hao Chen, Bin Shen, Honghui Ma, Yi-HanChen. Depletion of m6A reader protein YTHDC1 induces dilated cardiomyopathy byabnormal splicing of Titin. Journal of Cellular and Molecular Medicine, online, October 30, 2021. 25(23): 10879-10891 Doi: 10.1111/jcmm.16955. 13. Ge Guo, Giuliano Giuseppe Stirparo, Stanley E. Strawbridge, DanielSpindlow, Jian Yang, James Clarke, Anish Dattani, Ayaka Yanagida, MengAmy Li, Sam Myers, Buse Nurten Ozel, Jennifer Nichols, and Austin Smith. Humannaïve epiblast cells possess unrestricted lineage potential. Cell Stem Cell,online April 7, 2021.31(9): 951-964 Doi.org/10.1016/j.stem.2021.02.025. 14. Duanyang Xie, Ke Xiong, Xuling Su, Guanghua Wang,Qiang Ji, Qicheng Zou, Lingling Wang, Yi Liu, Dandan Liang, Jinfeng Xue, LuxingWang, Xueting Gao, Xingdong Gu, Hongyu Liu, Xiaoyu He, Li Li, Jian Yang, YoumingLu, Luying Peng, Yi-Han Chen. Identification of an endogenous glutamatergic transmittersystem controlling excitability and conductivity of atrial cardiomyocytes. Cell Research, online 06 April 2021. 31(9): 951-964 Doi: 10.1038/s41422-021-00499-5. 15. Yanping Zhang, Le Ni, BowenLin, Lingjie Hu, Zheyi Lin, Jian Yang, Jinyu Wang, Honghui Ma, Yi Liu, Jian Yang, Jianghua Lin, Liang Xu, Liqun Wu and Dan Shi. SNX17 protects theheart from doxorubin-induced cardiotoxicity by modulating LMOD2 degradation. Pharmacological Research, 2021, 169: 105642. Online, April 30, 2021. Doi: 10.1016/j.phrs.2021.105642. 16. DandanLiang, Zhigang Xue, Jinfeng Xue, Duanyang Xie, Ke Xiong, Huixing Zhou, FuleiZhang, Xuling Su, Guanghua Wang, Qicheng Zou, Yi Liu, Jian Yang, Honghui Ma, Luying Peng, Chunyu Zeng, Gang Li, Li Wangand Yi-han Chen. Sinoatrial node pacemaker cells share dominant biological propertieswith glutamatergic neurons. Protein& Cell, online, February6, 2021. 12(7): 545-556 Doi.org/10.1007/s13238-020-00820-9. 17. DandanLiang, Jinfeng Xue, Li Geng, Liping Zhou, Bo Lv, Qiao Zeng, Ke Xiong, HuixingZhou, Duanyang Xie, Fulei Zhang, Jie Liu, Yi Liu, Li Li, Jian Yang, ZigangXue and Yi-Han Cheng. Cellular and molecular landscape of mammalian sinoatrialnode revealed by single-cell RNA sequencing. Nature Communications, 2021, 12: 287. 18. DuanyangXie, Li Geng, Ke Xiong, Tingting Zhao, Shuo Wang, Jinfeng Xie, Cheng Wang, GuanghuaWang, Zhiqiang Feng, Huixing Zhou, Yini Li, Li Li, Zhigang Xue, Jian Yang, HonghuiMa, Dandan Liang and Yi-Han Chen. Cold-inducible RNA-binding protein prevents anexcessive heart rate response to stress by targeting phosphodiesterase. Circulation Research, 2020, 126: 1706-1720. 19. Jinyu Wang, Bowen Lin, Yanping Zhang, Le Ni, Lingjie Hu, Jian Yang, Liang Xu,Dan Shi and Yi-Han Cheng. The regulatory role of histone modification on geneexpression on the early stage of myocardial infarction. Frontiers in Cardiovascular Medicine, 2020, 7: 594325. 20. DuanyangXie, Li Geng, Shuo Wang, Ke Xiong, Tingting Zhao, Guanghua Wang, Zhiqiang Feng,Fei Lv, Cheng Wang, Dandan Liang, Dan Shi, Xiue Ma, Yi Liu, Jian Yang, Chao Zhang and Yi-Han Chen. Cold-inducible RNA-bindingprotein modulates atrial fibrillation onset by targeting multiple ion channels. Heart Rhythm, 2020, Jan 7, pii: S1547-5271(20)30002-3. 21. Adam C. Wilkinson, David J.Ryan, Iwo Kucinski, Wei Wang, Jian Yang, Sonia Nestorowa, Evangelia Diamanti, JasonCheuk-Ho Tsang, Juexuan Wang, Lia S. Campos, Fengtang Yang, Beiyuan Fu, NicolaWilson, Pentao Liu and Berhold Gottgens. Expanded potential stem cell media asa tool to study human hematopoiesis in vitro. Experimental Hematology,  2019, 76:1-12.e5. 22. Xuefei Gao,Monika Nowak-Imialek, Xi Chen, Dongsheng Chen, Doris Herrmann, Degong Ruan,Andy Chun Hang Chen, Melanie A. Eckersley-Maslin, Shakil Ahmad, Yin Lau Lee,Toshihiro Kobayashi, David Ryan, Jixing Zhong, Jiacheng Zhu, Jiacheng Zhu, Jian Wu, Guocheng Lan, Stoyan Petkov, JianYang, Liliana Antunes, Lia S. Campos, Beiyuan Fu, Shengpeng Wang, Yu Yong,Xiaoming Wang, Song-Guo Xue, Liangpeng Ge, Zuohua Liu, Yong Huang, Tao Nie,Peng Li, Donghai Wu, DUanqing Pei, Yi Zhang, Liming Lu,  Fengtang Yang, Susan J. Kimber, Wolf Reik,Xiangang Zou, Zhouchun Shang, Liangxue Lai, Azim Surani, Patrick P.L. Tam, Asif Ahmed, William Shu Biu Yeung, SarahA. Teichmann, Heiner Niemann and Pentao Liu. Establishment of porcine and humanexpanded potential stem cells. Nature Cell Biology, 2019, 21, 687-699. 23. Jindun Zhang, Xuefei Gao, Jian Yang, Xiaoying Fan, Wei Wang, YanfengLiang, Lihong Fan, Hongmei Han, Xiaorong Xu, Fuchou Tang, Siqin Bao, Pentao Liuand Xihe Li. Xist intron 1 repression by TALE designer transcriptional factorimproves somatic cell reprogramming in mice. Stem Cells, 2019, 37(5): 599-608. DOI: 10.1002/stem.2928. 24. LixiaZhao, Zixin Wang, Jindun Zhang, JianYang, Xuefei Gao, Baojiang Wu, Gaoping Zhao, Siqin Bao, Shuxiang Hu, PentaoLiu and Xihe Li. Characterization of the single-cell derived bovine inducedpluripotent stem cells. Tissue and Cell, 2017, 49: 521-527. 25. Xuefei Gao, Jian Yang, Jason Tsang, JoleneOoi, Donghai Wu and Pentao Liu. Reprogramming to Pluripotency Using DesignerTALE Transcription Factors Targeting Enhancers. Stem Cell Reports, 2013, 1(2): 183-197.26. Wei Wang, Jian Yang, Hui Liu, Dong Lu, Xiongfeng Chen , Zenon Zenonos, Lia S. Campos, Roland Rad, Ge Guo, Shujun Zhang, Allan Bradley, and Pentao Liu. Rapid and efficient reprogramming of somaticcells to induced pluripotent stem cells by retinoic acid receptor gamma andliver receptor homolog 1. Proc Natl Acad Sci U.S.A, 2011,108(45): 18283-18288.27. Ge Guo, Jian Yang, Jennifer Nichols, John Simon Hall, Isobel Eyres,William Mansfield and Austin Smith. Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development, 2009, 136(7): 1063-1069.28. Mia Buehr, Stephen Meek,Kate Blair, Jian Yang, Janice Ure, Jose Silva, Renee McLay, John Hall, Qi-Long Ying and Austin Smith. Capture of Authentic Embryonic Stem Cells from Rat Blastocysts. Cell, 2008, 135(7): 1287-1298.专利1. Cells and methods for obtaining them. Liu Pentao, Wang Wei, Yang Jian. CA 2773291A1; US2012/0315703 A1; SG 178613 A1;CN 102822345A; SG10201405455U A; US 9512407 B2;EP 2475774A1; WO 2011/027180A1.2. In vitroproduction of expanded potential stem cells. Liu Pentao, Ryan David, Gao Xuefei,Wang Wei, Yang Jian. WO 2016/079146A1; US 10745760 B2 学生信息 研究生 刘军阳 熊惠 张明帅 学生信息 当前位置：教师主页 > 学生信息 入学日期 所学专业 学号 学位 招生信息 当前位置：教师主页 > 招生信息 招生学院 招生专业 研究方向 招生人数 推免人数 考试方式 招生类别 招生年份