曹莹教师主页

个人简介 Personal Profile 同济大学教授、博导，2011年获上海市浦江人才计划，2022年获湖北省自然科学奖二等奖。在清华大学获得本科和博士学位，在耶鲁大学医学院遗传系完成博士后训练。自入职同济以来，建立了独立的科研团队和实验平台，旨在以斑马鱼为模型、以多囊肾和视网膜退行性疾病为切入点、研究纤毛相关的信号通路在发育和疾病中的作用机制。 研究方向Research Directions 遗传、发育与疾病 2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容：在对机电结构进行分析和优化的基础上，运用控制理论进行结构参数的调整，使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容：以仿生结构为研究对象，运用连续体结构拓扑优化设计理论和方法，对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。 团队展示 项目情况 获得十余项国家级或省部级科研项目。项目编号项目类别题目32170835自然科学基金面上项目核孔蛋白Nup62l在胚胎发育中的功能与机制研究31970767自然科学基金面上项目纤毛相关新因子的筛选及功能分析31771597自然科学基金面上项目Joubert综合征致病基因在纤毛生成和器官发育中的功能及机制31571515自然科学基金面上项目磷酸肌醇在纤毛和多囊肾形成中的作用及机制研究2017YFA0104600国家重点研究发展计划人类上皮细胞再生机制研究31171412自然科学基金面上项目系统地研究细胞极性与纤毛生成及多囊肾发生的关系2012CB966601科技部重大专项体内中胚层干细胞的自我更新与分化2013CB945300科技部重大专项心肌分化增殖与心脏发育再生的机制研究2011DFB30010国家国际科技合作与交流专项项目干细胞治疗的基础与临床前研究及产品研发20110072120047新教师类基金（博士点基金）斑马鱼多囊肾模型中细胞成群迁移的变化及其机制研究11PJ1409100浦江人才计划平面细胞极性信号通路在多囊肾疾病中的作用及机制研究 报考意向 招生信息 生命科学与技术学院 硕士研究生 序号 专业 招生人数 年份 1 生物学 1 2023 报考意向 姓名: 手机号码： 邮箱： 毕业院校： 所学专业： 报考类型： 博士 硕士 个人简历*： 上传附件 支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg 成绩单*： 上传附件 支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg 其他材料： 上传附件 支持扩展名：.rar .zip .doc .docx .pdf .jpg .png .jpeg 备注： 提交 科研项目 获得十余项国家级或省部级科研项目。 项目编号 项目类别 题目 32170835 自然科学基金面上项目 核孔蛋白Nup62l在胚胎发育中的功能与机制研究 31970767 自然科学基金面上项目 纤毛相关新因子的筛选及功能分析 31771597 自然科学基金面上项目 Joubert综合征致病基因在纤毛生成和器官发育中的功能及机制 31571515 自然科学基金面上项目 磷酸肌醇在纤毛和多囊肾形成中的作用及机制研究 2017YFA0104600 国家重点研究发展计划 人类上皮细胞再生机制研究 31171412 自然科学基金面上项目 系统地研究细胞极性与纤毛生成及多囊肾发生的关系 2012CB966601 科技部重大专项 体内中胚层干细胞的自我更新与分化 2013CB945300 科技部重大专项 心肌分化增殖与心脏发育再生的机制研究 2011DFB30010 国家国际科技合作与交流专项项目 干细胞治疗的基础与临床前研究及产品研发 20110072120047 新教师类基金（博士点基金） 斑马鱼多囊肾模型中细胞成群迁移的变化及其机制研究 11PJ1409100 浦江人才计划 平面细胞极性信号通路在多囊肾疾病中的作用及机制研究 研究成果 在PNAS、Dev Cell、JASN等高影响力期刊发表论文近40篇，获得专利一项。1.     Wenyan Xu, Miaomiao Jin, Ruikun Hu, Hong Wang, Fan Zhang, Shiaulou Yuanand Ying Cao*. The Joubert Syndrome Protein Inpp5eControls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. Journal of the American Society ofNephrology, 2017 Jan;28(1):118-129. (highlightedin Nature Reviews Nephrology,2016, 12: 508)2.     Zhang, Haijiao; Lin, Lin; Liu, Jianping; Pan, Lifeng; Lin, Zhijie; Zhang,Mingjie; Zhang, Jiong; Cao, Ying; Zhu, Jinwei*; Zhang,Rongguang*. Phase Separation of MAGI2-Mediated Complex Underlies Formation ofSlit Diaphragm Complex in Glomerular Filtration Barrier. Journal of theAmerican Society of Nephrology, 2021, 32(8): 1946-1960. DOI:10.1681/ASN.20201115903.     Miaomiao Jin#, Jingyu Li#, Ruikun Hu, Baijie Xu, Guanliang Huang, WeilaiHuang, Bo Chen, Jie He & Ying Cao*. CyclinA2/cyclin-dependent kinase 1–dependent phosphorylation of Top2a is required forS phase entry during retinal development in zebrafish. Journal of Geneticsand Genomics. 2021 Jan 20; 48(1): 63-74. doi:10.1016/j.jgg.2021.01.001."4.     Hanjing Wei, Yanhua Xu, Yibin Wang, Liting Xu, Chunyang Mo, Liangzi Li, BoShen, Yao Sun, Pengzhen Cheng, Liu Yang, Yichuan Pang, An Qin, Ying Cao,Sean J Morrison, Rui Yue*. Identification of Fibroblast Activation Protein asan Osteogenic Suppressor and Anti-osteoporosis Drug Target. Cell Rep.2020 Oct 13;33(2):108252.5.     Xueyu Li, Qiang Lu, Yuanyuan Peng, Fang Geng, Xuelian Shao, Huili Zhou, YingCao & Ruilin Zhang*. Primary cilia mediate Klf2-dependant Notchactivation in regenerating heart. Protein & Cell 2020Jun;11(6):433-445. doi: 10.1007/s13238-020-00695-w.6.     Jian Zhu, Han-Tsing Wang, Yu-Rong Chen, Ling-Ya Yan, Ying-Ying Han,Ling-Yan Liu, Ying Cao, Zhi-Zhi Liu, Hong A Xu. The JoubertSyndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish.Neurosci. Bull. September, 2020, 36(9):1023–10347.     Yonghua Sun, Bo Zhang, Lingfei Luo, De-Li Shi, Han Wang, Zongbin Cui,Honghui Huang, Ying Cao, Xiaodong Shu, Wenqing Zhang, JianfengZhou,Yun Li, Jiulin Du, Qingshun Zhao, Jun Chen, Hanbing Zhong, Tao P. Zhong,Li Li, Jing-Wei Xiong, Jinrong Peng, Wuhan Xiao, Jian Zhang, Jihua Yao, ZhanYin, Xianming Mo, Gang Peng, Jun Zhu, Yan Chen, Yong Zhou, Dong Liu, WeijunPan, Yiyue Zhang, Hua Ruan, Feng Liu, Zuoyan Zhu, Anming Meng, and The ZAKOCConsortium. Systematic genome editing of the genes on zebrafish Chromosome 1 byCRISPR/Cas9. Genome Research, 2020.8.     Yufei Feng, Ping Yu, Jingyu Li, Ying Cao, Jingjing Zhang.Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafishotic vesicle. Journal of Genetics and Genomics, 2020 Oct20;47(10):627-636.9.     Miaomiao Jin, Wenyan Xu, Hong Wang and Ying Cao*. Claudin-7band Claudin-h are required for controlling cilia morphogenesis in the zebrafishkidney. Mechanisms of Development. 2020 Mar;161:103595. doi:10.1016/j.mod.2019.103595. Epub 2019 Dec 27.10.  Yongzhan Sun, Zhiheng Liu, Xinyi Cao, Yi Lu, Zeyun Mi, Chaoran He, JingLiu, Zhanye Zheng, Mulin Jun Li, Tiegang Li, Dechao Xu, Ming Wu , YingCao, Yuhao Li, Baoxue Yang, Changlin Mei, Lirong Zhang, Yupeng Chen.Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystickidney disease. SCIENCE ADVANCES. 2019; 5 : eaaw359311.  Ruikun Hu, Weilai Huang, Miaomiao Jin, JiangfangLiu, Yue Wu,Jingyu Li, Zehao Yu, Hong Wang, and YingCao*. Mutagenesis of ciliary candidate genes with CRISPR/Cas9 system inzebrafish identifies genes required for retina development. FASEB J. 201912.  Wenyan Xu, Miaomiao Jin, Weilai Huang, Ruikun Hu, Hong Wang, Jingyu Li andYing Cao*. ApicalPtdIns(4,5)P2 is required for ciliogenesis and suppression of polycystic kidneydisease. FASEB J. 201913.  R. Sun, Y. Wang, M. Jin, L. Chen1, Y.Cao*, and F. Chen*. Identification and Functional Studies of MYO1H forMandibular Prognathism. Journal of Dental Research, 2018: 1–9 (*共通讯)14.  Xu D, Lv J, He L, Fu L, Hu R, CaoY*, Mei C*. Scribble influences cyst formation in autosomal-dominantpolycystic kidney disease by regulating Hippo signaling pathway. FASEB J. 2018 Mar. (*共通讯) 15.  Yunru Chen, Shiyang Zeng, Ruikun Hu, Weilai Huang, Xiangxiu Wang,Jiangfang Liu, Luying Wang, Guifen Liu, YingCao* and Yong Zhang*. Using local chromatin structure to improveCRISPR/Cas9 efficiency in zebrafish. PLoSOne，2017 Aug 11，12(8):e0182528. (*共通讯) 16.  Yonghua Sun, Bo Zhang, LingfeiLuo, De-Li Shi, Han Wang, Zongbin Cui, Honghui Huang, Ying Cao, Xiaodong Shu, Wenqing Zhang, Jianfeng Zhou, YunLi, Jiulin Du, Qingshun Zhao, Jun Chen, Hanbing Zhong, Tao P. Zhong, Li Li,Jing-Wei Xiong, Jinrong Peng, Wuhan Xiao, Jian Zhang, Jihua Yao, Zhan Yin,Xianming Mo, Gang Peng, Jun Zhu, Yan Chen, Yong Zhou, Dong Liu, Weijun Pan,Yiyue Zhang, Hua Ruan, Feng Liu, Zuoyan Zhu, Anming Meng, and The ZAKOCConsortium. Systematic genome editing of the genes on zebrafish Chromosome 1 byCRISPR/Cas9. Genome Research, 2020.17.  Xueqian Wang, Haitao Hou, Kaida Song, Zhiqiang Zhang, Shuqiang Zhang, Ying Cao, Liming Chen, QingSang, Fang Lin and Hui Xu. (2018). Lpar2b Controls Lateral Line Tissue Size byRegulating Yap1 Activity in Zebrafish. Frontiers in Molecular Neuroscience,18.  Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkey D, YuY, Tang J, Flockerzi V, Cao Y,Cao E, Chen XZ. Hydrophobic pore gates regulate ion permeation in polycystickidney disease 2 and 2L1 channels. Nat Commun. 2018 Jun 13;9(1):2302.19.  Zheng W, Hu R, Cai R, Hofmann L, Hu Q, Fatehi M, Long W, Kong T, Tang J,Light P, Flockerzi V, Cao Y,Chen XZ. Identification and characterization of hydrophobic gate residues inTRP channels. FASEB J. 2018Feb;32(2):639-65320.  Xiaoyu Zhao, Miaomiao Jin, Mengzhu Wang, Lili Sun, Xuejiao Hong, Ying Cao & Chunguang Wang. Fidgetin-like1 is a ciliogenesis-inhibitory centrosome protein. Cell Cycle. 2016Sep;15(17):2367-75.21.  Wang Zheng, Fan Shen, Ruikun Hu, Birbickram Roy, JungWoo Yang, Qian Wang,Fan Zhang, Jennifer C. King, Consolato Sergi, Song-Mei Liu, Emmanuelle Cordat,Jingfeng Tang, Ying Cao, Declan Ali and Xing-Zhen Chen. FarUpstream Element-Binding Protein 1 Binds the 3' Untranslated Region of PKD2 andSuppresses Its Translation. Journal ofthe American Society of Nephrology 2016; 2722. Liangliang He, Wenyan Xu,Ying Jing, Ming Wu, Shuwei Song, Ying Cao*, Changlin Mei*.Yes-Associated Protein (Yap) Is Necessary for Ciliogenesis and Morphogenesisduring Pronephros Development in Zebrafish (Danio Rerio). Int J Biol Sci2015; 11(8):935-947. （*共通讯）23.  Hussein S, Zheng W, Dyte C,Wang Q, Yang J, Zhang F, Tang J, Cao Y, Chen XZ. Acid-induced off-responseof PKD2L1 channel in Xenopus oocytes and its regulation by Ca(2.). Sci Rep.2015 Oct 27;5:15752. doi: 10.1038/srep15752.24.  Zheng W, Hussein S, Yang J,Huang J, Zhang F, Hernandez-Anzaldo S, Fernandez-Patron C, Cao Y, Zeng H, Tang J, Chen XZ. A novel PKD2L1 C-terminaldomain critical for trimerization and channel function. Sci Rep. 2015 Mar 30;5:946025.  Ma X, Chen Y, Xu W, Wu N, Li M,Cao Y, Wu S, Li Q, Xue L. ImpairedHippo signaling promotes Rho1-JNK-dependent growth. PNAS, 2015 Jan 27;112(4):1065-70.26.  Zhao L, Yuan S, Cao Y, Kallakuri S, Li Y,Kishimoto N, Dibella L, Sun Z.Reptin/Ruvbl2 is a Lrrc6/Seahorse interactoressential for cilia motility. PNAS,110(31):12697-70227.  Cao, Y#, Park, A. and Sun, Z. (2010). IntraflagellarTransport Proteins Are Essential for Cilia Formation and for Planar CellPolarity. J Am Soc Nephrol.21(8):1326-33. (封面文章)28.  Cao, Y.#, Semanchik N, Lee SH, Somlo S, Barbano PE, Coifman R, Sun Z. (2009).Chemical modifier screen identifies HDAC inhibitors as suppressors of PKDmodels. PNAS, 106(51):21819-2182429.  Kishimoto, N., Cao, Y.,Park, A., and Sun, Z. (2008). Cystic Kidney Gene seahorse RegulatesCilia-Mediated Processes and Wnt Pathways. Dev Cell, 14:954-961.30.  Rui, Y.#, Xu, Z.#, Xiong, B.#, Cao,Y.#, Lin, S., Zhang, M., Chan, SC., Luo, W., Han, Y., Lu, Z., Ye, Z.,Zhou, HM., Han, J., Meng, A., and Lin, SC. (2007). A beta-catenin-independentdorsalization pathway activated by Axin/JNK signaling and antagonized by aida. DevCell, 13(2):268-82. (#并列第一作者)31.  Huang, H., Lu, F., Jia, S.,Meng, S., Cao, Y., Wang, Y., Ma, W., Yin, K., Wen, Z., Peng, J.,Thisse, C., Thisse, B., and Meng, A. (2007). Amotl2 is essential for cellmovements in zebrafish embryo and regulates c-Src translocation. Development,134:979-988.32.  Cao, Y.#, Zhao, J., Sun, Z., Zhao, Z., Postlethwait, J., and Meng, A.(2004). fgf17b, a novel member of Fgf family, helps patterning zebrafishembryos. Dev Biol, 271:130-143.33.  Zhao, J., Cao, Y.,Zhao, C., Postlethwait, J., and Meng, A. (2003). An SP1-like transcriptionfactor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. EmboJ, 22:6078-6088.34.  Cao, Y.#, Zhao, J., Wang, Y., and Meng, A. (2003). Expression of zebrafishLc3 synthase gene in embryonic lens requires hedgehog signaling. Dev Dyn,228:308-312.35.  Li, M., Cao, Y., Zhao, Z., Lin, S., and Meng, A. (2001). Characterizationand expression pattern of pouII1 , a novel class II POU gene in zebrafish. Chin Sci Bull, 46(18):1523-1527.36.  Zhao, Z.#, Cao, Y.#,Li, M., and Meng, A. (2001). Double-stranded RNA injection produces nonspecificdefects in zebrafish. Dev Biol, 229:215-223. (#并列第一作者)专利：曹莹，王宏，许纹衍。一种磷脂酰肌醇3-激酶抑制剂的应用。2019。专利号：ZL 2015 1 0171337.3 学生信息 当前位置：教师主页 > 学生信息 入学日期 所学专业 学号 学位 招生信息 当前位置：教师主页 > 招生信息 招生学院 招生专业 研究方向 招生人数 推免人数 考试方式 招生类别 招生年份