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登录 山东大学 English 首页 科学研究 研究领域 论文成果 专利 著作成果 科研项目 科研团队 教学研究 教学资源 授课信息 教学成果 获奖信息 招生信息 学生信息 我的相册 教师博客 高洪银 498 个人信息Personal Information 教授 博士生导师 硕士生导师 性别：男 毕业院校：华东师范大学 学历：博士研究生毕业 学位：理学博士学位 在职信息：在职 所在单位：化学与化工学院 入职时间：2016-11-22 学科：有机化学 办公地点：济南市山大南路27号山东大学中心校区生命北楼514室 联系方式：0531-88361236 其他联系方式Other Contact Information 办公室电话 : 0531-88361236 扫描关注 个人简介Personal Profile 基本信息： 姓名: 高洪银 出生年月:  1983年7月 学历：博士研究生 职称:    教授（博士生导师）、“青年泰山学者”、“齐鲁青年学者” 单位:    有机化学与化学生物学研究中心 研究方向:  弱键断裂驱动的有机合成化学 地址:  山东省济南市山大南路27号生命北楼514室（实验室528/530） 办公电话:  0531-88361236 Email:    hygao@sdu.edu.cn   主要经历： 2016.11 -  至今        山东大学    教授、博士生导师 2015.05 - 2016.10   美国莱斯大学  博士后    2012.01 - 2015.05   美国德州大学西南医学中心  博士后    2011.09 - 2011.12    北京大学深圳研究生院    研究助理     2006.09 - 2011.07    华东师范大学    博士     2001.09 - 2006.07    泰山学院      学士   主讲课程： （1）有机化学（化学基地班本科生） （2）大学化学（III）（口腔医学院本科生） （3）有机化学实验（化学强基班本科生） （4）有机化学前沿领域导论（有机化学专业博士生）   研究方向： （1）含氮功能分子的创制及应用 （2）新型官能团化反应试剂的设计、开发与应用 （3）基于[2,3]、 [3,3]-重排反应的串联反应研究 （4）有机合成工艺研发与产业化应用   科研项目： （1）国家自然科学基金（面上项目），22271176，主持，2023.1-2026.12 （2）山东省“青年泰山学者”人才项目，主持，2023.1-2025.12 （3）国家自然科学基金（青年项目），21702122，主持，2018.1-2020.12 （4）山东省自然科学基金（面上项目），ZR2017MB002，主持，2017.8-2020.6 （5）山东省重点研发计划（公益类专项），2019GSF108056，主持，2019.1-2021.12 （6）“齐鲁青年学者”科研启动经费，主持，2016.12-2021.11 （7）企业合作研发项目（11项），主持 本课题组急招2名具备有机合成化学背景的科研助理(硕士及以上)； 常年招收有机化学及计算化学方向博士后，待遇优厚，欢迎咨询! 2024年招收科学学位(有机化学)、专业学位(材料与化工)的研究生。 欢迎广大考生积极报考！一起为梦想而奋斗！ 山东大学独立研究成果： 17. Zhenguo Xi, Xi-Jia Liu, Zhaoquan Guo, Zhiwei Gao, Zhi-Xiang Yu*, Hongyin Gao* “Regioselective umpolung para-C-H functionalization of arylhydroxylamines” Nat. Synth.2023, 2, 778-788. (Link) 16. Xiao Liu, Jingtai Pei, Zhiwei Gao, Hongyin Gao* “Synthesis of ortho-Phosphated (Hetero)Arylamines through Cascade Atherton−Todd Reaction/[3,3]-Rearrangement from Arylhydroxylamines and Dialkyl Phosphites” Org. Lett. 2022, 24, 7690-7695. (Link) 15. Gaofei Xu, Zongtao Han, Lirong Guo, Haifeng Lu*, Hongyin Gao* “Transition-Metal-Free Cascade Approach for the Synthesis of Functionalized Biaryls by SNAr of Arylhydroxylamines with Arylsulfonium Salts” J. Org. Chem. 2022, 87, 10449-10453. (Link) 14. Yue Liu, Gaofei Xu, Hongyin Gao* “[2,3]-Sigmatropic Rearrangement of Arylhydroxylamines: Rapid Access to ortho-Sulfonylated Anilines” Synlett 2022, 33, 1675-1680. (Invited Synpacts Highlight) (Link)   13. Min Wang,† Xiao Liu,† Liying Wang, Haifeng Lu,* Hongyin Gao* “Cooperative Gold/Zinc-catalyzed Cascade Approach to Tryptophan Derivatives from N-arylhydroxylamines and Alkynes” Asian J. Org. Chem. 2022, 11, e202200054. (Link) († Equal contribution) 12. Yue Liu, Songlin Bai, Yuanbo Du, Xiangbing Qi,* Hongyin Gao* “Expeditious and Efficient ortho-Selective Trifluoromethane-sulfonylation of Arylhydroxylamines” Angew. Chem. Int. Ed. 2022, 61, e202115611. (Hot Paper) (Link) 11. Zhuyong Zhang, Junfei Luo,* Hongyin Gao* “Rapid Access to Fluorinated Anilides via DAST-Mediated Deoxyfluorination of Arylhydroxylamines” Org. Lett. 2021, 23, 9332-9336. (Link) 10. Fengting Liu, Min Wang, Jiatong Qu, Haifeng Lu,* Hongyin Gao* “Synthesis of non-C2 symmetrical NOBIN-type biaryls through a cascade N-arylation and [3,3]- sigmatropic rearrangement from O-arylhydroxylamines and diaryliodonium salts” Org. Biomol. Chem. 2021, 19, 7246-7251. (Link) 9. Yuanbo Du, Zhenguo Xi, Lirong Guo, Haifeng Lu,* Lei Feng, Hongyin Gao* “Practical bromination of arylhydroxylamines with SOBr2 towards ortho-bromoanilides” Tetrahedron Lett. 2021, 72, 153074. (Link) 8. Min Wang, Yue Liu, Liying Wang, Haifeng Lu,* Lei Feng and Hongyin Gao* “Cascade Chan-Lam C- O Coupling/[3,3]-Rearrangement of Arylhydroxylamines with Arylboronic Acids Toward NOBIN Analogues” Adv. Synth. Catal. 2021, 363, 1733-1738. (Link) 7. Hairui Yuan,† Yuanbo Du,† Fengting Liu, Lirong Guo, Qianyu Sun, Lei Feng, and Hongyin Gao* “Tandem approach to NOBIN analogues from arylhydroxylamines and diaryliodonium salts via [3,3]-sigmatropic rearrangement” Chem. Commun. 2020, 56, 8226-8229. (Link) († Equal contribution) 6. Lirong Guo,† Fengting Liu,† Liying Wang, Hairui Yuan, Lei Feng, Haifeng Lu* and Hongyin Gao* “Transition-metal-free aerobic C–O bond formation via C–N bond cleavage” Org. Chem. Front. 2020, 7, 1077-1081. (Link) († Equal contribution) 5. Hairui Yuan, Min Wang, Zhenghu Xu*, and Hongyin Gao* “Palladium-Catalyzed Annulation of Aryltriazoles and Arylisoxazoles with Alkynes” Adv. Synth. Catal. 2019, 361, 4386-4392. (Link) 4. Lirong Guo,† Fengting Liu,† Liying Wang, Hairui Yuan, Lei Feng, Laszlo Kürti, and Hongyin Gao* “Cascade Approach to Highly Functionalized Biaryls by a Nucleophilic Aromatic Substitution with Arylhydroxylamines” Org. Lett. 2019, 21, 2894-2898. (Link) († Equal contribution) 3. Hairui Yuan, Lirong Guo, Fengting Liu, Zechen Miao, Lei Feng, and Hongyin Gao* “Copper-Catalyzed Tandem O-Vinylation of Arylhydroxylamines /[3,3]-Rearrangement/Cyclization: Synthesis of Highly Substituted Indoles and Benzoindoles” ACS Catal. 2019, 9, 3906-3912. (Link) 2.  Hairui Yuan, Thirupathi Nuligonda, Hongyin Gao, Chen-Ho Tung and Zhenghu Xu* “Copper-Catalyzed IntermolecularCarbene Insertion into S-S bond of Benzenesulfonothioate.” Org. Chem. Front. 2018, 5, 1371-1374. (Link)   1. KaitlynLovato,  Lirong Guo,  Qing-Long Xu, Fengting Liu,  Muhammed Yousufuddin,d  Daniel H. Ess,*  László Kürti* and Hongyin Gao* “Transition metal-free direct dehydrogenative arylation ofactivated C(sp3)–H bonds: synthetic ambit and DFT reactivity predictions.” Chem. Sci. 2018, 9, 7992-7999. (Link)   研究生及博士后期间成果： 15. Zhe Zhou, Zhiwei Ma, Nicole Erin Behnke1, Hongyin Gao and László Kürti.* “Non-Deprotonative Primary and Secondary Amination of (Hetero)Arylmetals.”  J. Am. Chem. Soc. 2017, 139, 115-118. (Link)   14. Hongyin Gao, Zhe Zhou, Doo-Hyun Kwon, James Coombs, Steven Jones, Nicole Erin Behnke1, Daniel H. Ess*, László Kürti.* “Rapid Heteroatom-Transfer to Arylmetals Utilizing Multifunctional Reagent Scaffolds.” Nat. Chem. 2017 9, 681-688. (Link) This paper was highlighted by C&EN (2016, 94 (48).) and X-Mol on December 7th, 2016.   13. Hongyin Gao,# Qing-Long Xu, # Craig Keene, Muhammed Yousufuddin, Daniel H. Ess, László Kürti.* “Practical Organocatalytic Synthesis of Functionalized Non-C2-Symmetrical Atropisomeric Biaryls.” Angew. Chem. Int. Ed. 2016, 55, 566-571. (Hot Paper) (Link) This paper was highlighted by C&EN (Chemical and Engineering News 2015, 93(48), 37.). # Contributed equally.   12. Hongyin Gao, Qing-Long Xu, Craig Keene, László Kürti.* “Scalable, Transition-Metal-Free Direct Oxime O-Arylation: Rapid Access to O-Arylhydroxylamines and Substituted Benzo[b]furans.” Chem. Eur. J. 2014, 20, 8883-8887. (Link)   11. Hongyin Gao, Qing-Long Xu, Muhammed Yousufuddin, Daniel H. Ess, László Kürti.* “Rapid Synthesis of Fused N-Heterocycles by Transition-Metal-Free Electrophilic Amination of Arene C-H Bonds.” Angew. Chem. Int. Ed. 2014, 53, 2701-2705. (Hot Paper) (Link) This paper was highlighted by SYNFACTS (Synfacts 2014, 10(4), 351.).   10. Jawahar L Jat, Mahesh P. Paudyal, Hongyin Gao, Qing-Long Xu, Muhammed. Yousufuddin, Deepa Devarajan, Daniel H. Ess, László Kürti,* J. R. Falck.* “Direct Stereospecific Synthesis of Unprotected N-H and N-Me Aziridines from Olefins.” Science 2014, 343, 61-65. (Link) This paper was highlighted by Science, Nature Chemistry,  Angewandte Chemie International Edition, Chemical and Engineering News and Chemistry World.   9. Qing-Long Xu, Hongyin Gao, Daniel H. Ess, László Kürti.* “Aerobic, Transition-Metal-Free, Direct and Regiospecific Mono-α-Arylation of Ketones: Synthetic Studies and Mechanism by DFT Calculations.” J. Am. Chem. Soc. 2013, 135, 14048-14051. (Link)   8. Gong-Qiang Li, Hongyin Gao, Craig Keene, Michael Devonas, Daniel H. Ess, László Kürti.* “Organocatalytic Aryl-Aryl Bond-Formation: An Atroposelective [3,3]-Rearrangement Approach to BINAM Derivatrives.” J. Am. Chem. Soc. 2013, 135, 7414-7417. (Link)   7. Hongyin Gao, Daniel H. Ess, M. Yousufuddin,  László Kürti.* “Transition- Metal-Free Direct Arylation: Synthesis of Halogenated 2-Amino-2’-Hydroxy-1,1’-Biaryls and Mechanism by DFT Calculations.”  J. Am. Chem. Soc. 2013, 135, 7086-7089. (Cover Paper) (Link) This paper was highlighted by JACS (J. Am. Chem. Soc. 2013, 135, 7081.),  SYNFACTS (Synfacts 2013, 9(8), 879.) and C&EN (Chemical and Engineering News 2013, 91(21), 40.).   6. Hongyin Gao, Junliang Zhang. “Catalytic Cascade Reactions”, Chap 6, 225-282. First Edition. Edited by Peng-Fei Xu and Wei Wang. John Wiley & Sons, Inc. 2014.   5. Hongyin Gao, Junliang Zhang.* “Cationic Rhodium(I)-Catalyzed Regioselective Tandem Hetero- cyclization/ [3+2] Cycloaddition of 2-(1-Alkynyl)-2-alken-1-ones with Alkynes.” Chem. Eur. J. 2012, 18, 2777-2782. (Link)   4. Hongyin Gao, Xingxing Wu, Junliang Zhang.* “Gold(I)-Catalyzed Highly Diastereo- selective Tandem Heterocyclization/[3+2] Cycloaddition: Synthesis of Highly Substituted Cyclopenta[c]furan.” Chem. Eur. J. 2011, 17, 2838-2841. (Link)   3. Hongyin Gao, Xingxing Wu, Junliang Zhang.* “Exo/endo selectivity-control in Lewis-acid catalyzed tandem hetero-cyclization/formal [4+3] cycloaddition: synthesis of polyheterocycles from 2-(1-alkyn-yl)-2-alken-1-ones and 1,3-diphenylisobenzofuran.” Chem. Commun. 2010, 46, 8764-8766. (Link)   2. Hongyin Gao, Xiaoli Zhao, Yihua Yu, Junliang Zhang.* “Highly Substituted Furo [3,4-c]azepines by Gold(I)-Catalyzed Diastereoselective Tandem Double Heterocyclizations and 1,2-Alkyl Migration.” Chem. Eur. J. 2010, 16, 456-459. (Link) This paper was highlighted by SYNFACTS ( Synfacts 2010, 3, 285.).   1. Hongyin Gao, Junliang Zhang. “A Dramatic Substituent Effect in Silver(I)-Catalyzed Regioselective Cyclization of ortho-Alkynylaryl Aldehyde Oxime Derivatives.” Adv. Synth. Catal. 2009, 351, 85-88. (Link)     专利： 9. 一类新型偶氮类发泡剂及合成方法，202211226153.9   8. 一种对位官能团化芳胺化合物及其合成方法，ZL 2022 1 0215790.X   7. 一种合成手性色氨酸衍生物的方法，ZL 2021 1 1175245.4   6. 一种含硫基二氢异恶唑类化合物及其合成方法，ZL 2021 1 1359078.9   5. 一种邻位磺酰化芳胺化合物及其合成方法，ZL 2021 1 1338392.9   4. NOBIN类联芳基化合物及其合成方法，ZL 2021 1 0109185.X   3. Hongyin Gao, László Kürti, and Zhe Zhou. “Amination and Hydroxylation of Arylmetal Compounds.” (US Provisional filed on 5/5/2016 by Rice University; IP Application # 62/366,483).   2. Hongyin Gao, László Kürti. “Transition Metal Free Methods of Synthesis of Biaryl Compounds.” (US Provisional patent filed on 11/9/2015 by Rice University. Now Converted: PCT/US2016/061628).   1. Carolyn L. Cannon, Hongyin Gao, László Kürti, Kush Nimish Shah, Parth Nimish Shah. “Biaryl Compounds as Antimicrobial and Chemotherapeutic Agents.” (US Provisional patent filed on 9/16/2015 jointly by Rice University and Texas A&M University. Now Converted: PCT/US2016/061607).   热忱欢迎对有机化学感兴趣的本科生、研究生、博士后、科研助理加入本课题组！ 无奋斗不青春，无拼搏不化学！期待与心怀梦想但又脚踏实地的人一起前行！！ 教育经历Education Background 工作经历Work Experience 暂无内容 暂无内容 研究方向Research Focus 社会兼职Social Affiliations 暂无内容 暂无内容 版权所有   ©山东大学　地址：中国山东省济南市山大南路27号　邮编：250100　查号台：（86）-0531-88395114值班电话：（86）-0531-88364731　建设维护：山东大学信息化工作办公室 　　12 手机版 访问量：0000045873次 开通时间： 2019.4.4 最后更新时间： 2024.4.17